Determination of the absolute configuration of sialic acids in gangliosides from the sea cucumber Cucumaria echinata

Fumiaki Kisa, Koji Yamada, Tomofumi Miyamoto, Masanori Inagaki, Ryuichi Higuchi

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

Enantiomeric pairs of sialic acid, D- and L-NeuAc (N-acetylneuraminic acid), were converted to D- and L-arabinose, respectively, by chemical degradation. Using this method, the absolute configuration of the sialic acid residues, NeuAc and NeuGc (N-glycolylneuraminic acid), in the gangliosides from the sea cucumber Cucumaria echinata was determined to be the D-form. Although naturally occurring sialic acids have been believed to be the D-form on the basis of biosynthetic evidence, this is the first report of the determination of the absolute configuration of the sialic acid residues in gangliosides using chemical methods.

本文言語英語
ページ(範囲)1051-1052
ページ数2
ジャーナルChemical and Pharmaceutical Bulletin
55
7
DOI
出版ステータス出版済み - 7 2007

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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