抄録
Enantioselective 1,1-diarylation of terminal alkenes enabled by the combination of Pd catalysis with a chiral anion phase transfer (CAPT) strategy is reported herein. The reaction of substituted benzyl acrylates with aryldiazonium salts and arylboronic acids gave the corresponding 3,3-diarylpropanoates in moderate to good yields with high enantioselectivies (up to 98:2 er). Substituents on the benzyl acrylate and CAPT catalyst significantly affect the enantioselectivity, and multidimensional parametrization identified correlations suggesting structural origins for the high stereocontrol.
本文言語 | 英語 |
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ページ(範囲) | 15877-15880 |
ページ数 | 4 |
ジャーナル | Journal of the American Chemical Society |
巻 | 138 |
号 | 49 |
DOI | |
出版ステータス | 出版済み - 12月 14 2016 |
!!!All Science Journal Classification (ASJC) codes
- 触媒
- 化学 (全般)
- 生化学
- コロイド化学および表面化学