Development and mechanical characterization of bilayer tubular scaffolds for vascular tissue engineering applications

Thanh Tam Tran, Zuratul Ain Abdul Hamid, Ngoc Thien Lai, Kuan Yew Cheong, Mitsugu Todo

研究成果: ジャーナルへの寄稿記事

抄録

Poly(l-lactide-co-ε-caprolactone) (PLCL) is a potential material to fabricate scaffolds for vascular tissue engineering. In this work, scaffolds with a multilayered structure comprising a combination of porous and fibrous structures were developed. PLCL was used to fabricate the inner layer of the tubular scaffolds using the freeze-drying technique. The inner layer was then covered by an outer layer fabricated by the melt-spinning technique. The morphology and physical structure of the scaffolds were evaluated through SEM micrographs. The freeze-drying technique formed a porous structure, while the melt-spinning method formed a fibrous structure for the bilayer scaffolds. Physicochemical properties were also investigated by DSC and FTIR measurements; no new functional groups were found to have formed during the freeze-drying or melt-spinning processes. Mechanical properties and fracture mechanism under a tensile loading condition were carefully analyzed to characterize the deformation and fracture behaviors. It was found that the bilayer scaffolds exhibited better mechanical properties than single-layer scaffolds with higher maximum stress at 675.41 kPa, strain at maximum stress at 69.42%, fracture energy at 412.45 kJ/m3 and burst pressure at 147.93 kPa. Porosity, swelling ratio and in vitro biodegradation were measured to ensure its suitability for vascular tissue applications. The bilayer scaffolds with both porous and fibrous structures meet the requirements for vascular tissue engineering.

元の言語英語
ページ(範囲)2516-2529
ページ数14
ジャーナルJournal of Materials Science
55
発行部数6
DOI
出版物ステータス出版済み - 2 1 2020

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Scaffolds (biology)
Tissue engineering
Scaffolds
Melt spinning
Drying
Mechanical properties
Fracture energy
Bioelectric potentials
Biodegradation
Functional groups
Swelling
Porosity
Tissue
Scanning electron microscopy

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

これを引用

Development and mechanical characterization of bilayer tubular scaffolds for vascular tissue engineering applications. / Tran, Thanh Tam; Hamid, Zuratul Ain Abdul; Lai, Ngoc Thien; Cheong, Kuan Yew; Todo, Mitsugu.

:: Journal of Materials Science, 巻 55, 番号 6, 01.02.2020, p. 2516-2529.

研究成果: ジャーナルへの寄稿記事

Tran, Thanh Tam ; Hamid, Zuratul Ain Abdul ; Lai, Ngoc Thien ; Cheong, Kuan Yew ; Todo, Mitsugu. / Development and mechanical characterization of bilayer tubular scaffolds for vascular tissue engineering applications. :: Journal of Materials Science. 2020 ; 巻 55, 番号 6. pp. 2516-2529.
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