Development and potential theranostic applications of a self-assembled hybrid of magnetic nanoparticle clusters with polysaccharide nanogels

Kiyofumi Katagiri, Keiko Ohta, Kaori Sako, Kei Inumaru, Koichiro Hayashi, Yoshihiro Sasaki, Kazunari Akiyoshi

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

抄録

A new organic-inorganic hybrid was generated by self-assembly of nanosized polymer hydrogels (nanogels) and Fe3O4 nanoparticles (NPs) for potential biomedical applications. By using the tetrahydrofuran (THF) injection method, hydrophobized Fe3O4 NPs were complexed through hydrophobic interactions with amphiphilic polysaccharide nanogels. The obtained hybrid showed high colloidal stability and dispersibility in aqueous media. The number of Fe3O4 NP aggregates was controlled by changing the concentration of the Fe3O4 NPs in THF. The hybrid displayed greater enhancement than existing contrast media in T2 magnetic resonance imaging because of the optimal agglomeration of Fe3O4 NPs following their complexation with nanogels. Furthermore, the hybrid generated heat in response to alternating magnetic-field irradiation. The increase in temperature was controlled by adjusting the concentration of the hybrid and the amplitude of the magnetic field, which indicates that the hybrid is also suitable for magnetic hyperthermia therapy.

元の言語英語
ページ(範囲)1631-1637
ページ数7
ジャーナルChemPlusChem
79
発行部数11
DOI
出版物ステータス出版済み - 11 2014
外部発表Yes

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Polysaccharides
Nanoparticles
Hyperthermia therapy
Magnetic fields
Hydrogels
Magnetic resonance
Complexation
Self assembly
Contrast Media
Polymers
Agglomeration
NanoGel
Irradiation
Imaging techniques
Temperature
tetrahydrofuran

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

これを引用

Development and potential theranostic applications of a self-assembled hybrid of magnetic nanoparticle clusters with polysaccharide nanogels. / Katagiri, Kiyofumi; Ohta, Keiko; Sako, Kaori; Inumaru, Kei; Hayashi, Koichiro; Sasaki, Yoshihiro; Akiyoshi, Kazunari.

:: ChemPlusChem, 巻 79, 番号 11, 11.2014, p. 1631-1637.

研究成果: ジャーナルへの寄稿記事

Katagiri, Kiyofumi ; Ohta, Keiko ; Sako, Kaori ; Inumaru, Kei ; Hayashi, Koichiro ; Sasaki, Yoshihiro ; Akiyoshi, Kazunari. / Development and potential theranostic applications of a self-assembled hybrid of magnetic nanoparticle clusters with polysaccharide nanogels. :: ChemPlusChem. 2014 ; 巻 79, 番号 11. pp. 1631-1637.
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AU - Hayashi, Koichiro

AU - Sasaki, Yoshihiro

AU - Akiyoshi, Kazunari

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