Development of a circulatory mock loop for biventricular device testing with various heart conditions

Yuichiro Kado, Takuma Miyamoto, David J. Horvath, Shengqiang Gao, Kiyotaka Fukamachi, Jamshid H. Karimov

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

This study aimed to evaluate a newly designed circulatory mock loop intended to model cardiac and circulatory hemodynamics for mechanical circulatory support device testing. The mock loop was built with dedicated ports suitable for attaching assist devices in various configurations. This biventricular mock loop uses two pneumatic pumps (Abiomed AB5000, Danvers, MA, USA) driven by a dual-output driver (Thoratec Model 2600, Pleasanton, CA, USA). The drive pressures can be individually modified to simulate a healthy heart and left and/or right heart failure conditions, and variable compliance and fluid volume allow for additional customization. The loop output for a healthy heart was tested at 4.2 L/min with left and right atrial pressures of 1 and 5 mm Hg, respectively; a mean aortic pressure of 93 mm Hg; and pulmonary artery pressure of 17 mm Hg. Under conditions of left heart failure, these values were reduced to 2.1 L/min output, left atrial pressure = 28 mm Hg, right atrial pressure = 3 mm Hg, aortic pressure = 58 mm Hg, and pulmonary artery pressure = 35 mm Hg. Right heart failure resulted in the reverse balance: left atrial pressure = 0 mm Hg, right atrial pressure = 30 mm Hg, aortic pressure = 100 mm Hg, and pulmonary artery pressure = 13 mm Hg with a flow of 3.9 L/min. For biventricular heart failure, flow was decreased to 1.6 L/min, left atrial pressure = 13 mm Hg, right atrial pressure = 13 mm Hg, aortic pressure = 52 mm Hg, and pulmonary artery pressure = 18 mm Hg. This mock loop could become a reliable bench tool to simulate a range of heart failure conditions.

本文言語英語
ページ(範囲)600-605
ページ数6
ジャーナルInternational Journal of Artificial Organs
43
9
DOI
出版ステータス出版済み - 9月 1 2020
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • バイオエンジニアリング
  • 生体材料
  • 生体医工学

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