Development of a portable surface plasmon resonance sensor with multi-sensing points based on the linear CCD sensor

Jie Zhan, Koji Furui, Hizuru Nakajima, Noriaki Kaneki, Ryoichi Ishimatsu, Koji Nakano, Toshihiko Imato, Akihide Hemmi

    研究成果: ジャーナルへの寄稿学術誌査読

    3 被引用数 (Scopus)

    抄録

    A portable-type surface plasmon resonance (SPR) sensor, composed from a new optical system for multi-sensing, has been developed to apply to environment analysis, clinical diagnosis etc., where many samples are desired to be analyzed at high throughput. The optical system of the sensor consists of a light-emitting diode, a pair of cylindrical lenses, a pair of collimator lenses, a correction lens, a prism, a polarizer and a linear CCD sensor with 2048 pixels. Reflected light from a sensor chip of the width of 6 mm at a certain incident angle was detected by ca. 618 pixels of the linear CCD sensor as an SPR sensor signal. An SPR sensor signal at a specified incident angle is controllable for optimization by adjusting the position of the CCD sensor. A sensor chip having a 30-stripe linear pattern (100 μm width/stripe) was prepared. The spatial resolution as well as the performance of the sensor were evaluated by using sucrose solutions. As a result, the acquisition of SPR sensor signals from 30 sensing points was successfully achieved with a spatial resolution of 100 μm (distance between 2 sensing points). A lower detection limit of ca. 3.2-5.5 × 10 -5 RIU with a standard deviation of ±4.5% was obtained by averaging the signals from 6-7 pixels of the CCD sensor per one sensing stripe. 2016.

    本文言語英語
    ページ(範囲)673-679
    ページ数7
    ジャーナルanalytical sciences
    32
    6
    DOI
    出版ステータス出版済み - 2016

    !!!All Science Journal Classification (ASJC) codes

    • 分析化学

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