Development of a protease-responsive protein nano capsule for drug carrier

Kentaro Sao, Masaharu Murata, Hiroki Sato, Tatsuhiko Sonoda, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, Makoto Hashizume

研究成果: 会議への寄与タイプ論文


Recently, researches of drug delivery systems (DDS) have been investigated actively. For the accomplishment of DDS, it is important to develop drug carriers. Wile a lot of efforts have been expended, there are no carriers which have enough efficiency. So, we aimed at one protein which is named HSP16.5 for the application to drug carriers. This protein affects nano capsule-like conformation. In many diseases, it is well known that certain proteases have overexpresssed at the lesion regions. We inserted protease recognition amino acid sequences to the HSP16.5. In the presence of target protease, this nano capsule composed of rHSP16.5 could collapse selectively, and it is expected to release the encapsulated drug at pathological areas.

出版物ステータス出版済み - 10 19 2006
イベント55th SPSJ Annual Meeting - Nagoya, 日本
継続期間: 5 24 20065 26 2006


その他55th SPSJ Annual Meeting


All Science Journal Classification (ASJC) codes

  • Engineering(all)


Sao, K., Murata, M., Sato, H., Sonoda, T., Mori, T., Niidome, T., ... Hashizume, M. (2006). Development of a protease-responsive protein nano capsule for drug carrier. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.