Development of a self-scored persistent airflow obstruction screening questionnaire in a general Japanese population: The Hisayama study

Takuya Samukawa, Koichiro Matsumoto, Go Tsukuya, Chihaya Koriyama, Satoru Fukuyama, Akifumi Uchida, Keiko Mizuno, Hironori Miyahara, Yutaka Kiyohara, Toshiharu Ninomiya, Hiromasa Inoue

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)


Background: The use of a simple screening questionnaire to detect persistent airflow obstruction (AO) in COPD may facilitate the early, accurate diagnosis of COPD in general practice settings. Objective: This study developed an original persistent AO questionnaire for screening individuals with COPD in a general Japanese population. Methods: A working group was established to generate initial draft questionnaire items about COPD. Eligible subjects aged 40 and older living in Japan were solicited to participate in a health checkup from 2014 to 2015. In study I, 2,338 subjects who fully completed the initial draft questionnaire and who had valid spirometry measurements were statistically analyzed to determine the final questionnaire items as a COPD screening questionnaire (COPD-Q). Persistent AO was defined as a post-bronchodilator FEV1/FVC <0.70. In study II, the working group analyzed the weighted scores for individual items and established a cutoff point for the COPD-Q based on the data of 2,066 subjects in the Hisayama study. Receiver operating characteristic (ROC) curves were used to examine the ability of the COPD-Q to discriminate between subjects with and without AO. Results: The five-item COPD-Q was established based on 19 initial draft items in study I and the weighted scores of individual items. The overall area under the ROC curve for the COPD-Q was 0.796 (95% confidence interval, 0.707–0.788). A cutoff of 4 points resulted in a sensitivity of 71.0% and a specificity of 70.1%. The positive predictive value was 10.8%, and the negative predictive value was 97.9%. The crude odds ratio of the COPD-Q for AO was 5.8. Conclusion: The five-item COPD-Q is a useful questionnaire for diagnosing persistent AO in a general Japanese population and is expected to be an effective first-stage screening tool for detecting COPD.

ジャーナルInternational Journal of COPD
出版ステータス出版済み - 5 15 2017

All Science Journal Classification (ASJC) codes

  • 呼吸器内科
  • 健康政策
  • 公衆衛生学、環境および労働衛生


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