TY - JOUR
T1 - Development of a sensitive trace bioanalysis system using microscale flow control and electrophoresis
AU - Kawai, Takayuki
N1 - Publisher Copyright:
© 2018 The Japan Society for Analytical Chemistry.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018
Y1 - 2018
N2 - Microscale analysis methods, such as microfluidic devices and capillary electrophoresis, can treat a pL~nL order solution rapidly and sensitively, so that they are expected to be basis of single-cell-level trace bioanalysis. Many researchers have tried to utilize these microscale analytical technologies for trace-level bioanalysis; however, practical single-cell-level analytical methods are quite limited. This is because the total designing of the analytical protocol is complicated and difficult when using many microscale basic techniques. We have also developed many basic technologies in the microscale analysis research area, as well as an actual application to single-cell analysis and so on by the smart combination of basic technologies. This review paper summarizes our achievements comprehensively.
AB - Microscale analysis methods, such as microfluidic devices and capillary electrophoresis, can treat a pL~nL order solution rapidly and sensitively, so that they are expected to be basis of single-cell-level trace bioanalysis. Many researchers have tried to utilize these microscale analytical technologies for trace-level bioanalysis; however, practical single-cell-level analytical methods are quite limited. This is because the total designing of the analytical protocol is complicated and difficult when using many microscale basic techniques. We have also developed many basic technologies in the microscale analysis research area, as well as an actual application to single-cell analysis and so on by the smart combination of basic technologies. This review paper summarizes our achievements comprehensively.
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U2 - 10.2116/bunsekikagaku.67.599
DO - 10.2116/bunsekikagaku.67.599
M3 - Review article
AN - SCOPUS:85061850007
VL - 67
SP - 599
EP - 606
JO - Bunseki Kagaku
JF - Bunseki Kagaku
SN - 0525-1931
IS - 10
ER -