Development of a three-dimensional micromixer device for production of various lipid-based nucleic acid nanocarriers

Niko Kimura, Masatoshi Maeki, Yusuke Sato, Kosuke Sasaki, Akihiko Ishida, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

抄録

This paper describes development of a three-dimensional (3D) baffle mixer device for precise size control of various types of lipid nanoparticles (LNPs) with high encapsulation efficiency of short interfering RNAs (siRNAs). The 3D baffle mixer device achieved more precise size control of various LNPs than that of the conventional micromixer device. In addition, the 3D baffle mixer enabled effective capturing of siRNAs into LNPs without any assistance of electrostatic interaction between lipid molecules and siRNAs. The 3D baffle mixer device is expected to become one of the key platforms for production of novel lipid-based nucleic acid nanocarriers.

本文言語英語
ホスト出版物のタイトル23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
出版社Chemical and Biological Microsystems Society
ページ368-369
ページ数2
ISBN(電子版)9781733419000
出版ステータス出版済み - 2019
外部発表はい
イベント23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, スイス
継続期間: 10月 27 201910月 31 2019

出版物シリーズ

名前23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

会議

会議23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
国/地域スイス
CityBasel
Period10/27/1910/31/19

!!!All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 化学工学(その他)

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