Development of acute megakaryoblastic leukemia from a minor clone in a Down syndrome patient with clinically overt transient myeloproliferative disorder

Gang Xu, Koji Kato, Tsutomu Toki, Yoshihiro Takahashi, Kiminori Terui, Etsuro Ito

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)

抄録

A Down syndrome male showed leukocytosis from birth and was diagnosed as transient myeloproliferative disorder (TMD). Eight months later, his condition had progressed to myelodysplastic syndrome after spontaneous resolution, and it then evolved to acute megakaryoblastic leukemia (AMKL) at the age of 20 months. Sequencing analysis showed that the predominant TMD and AMKL clones had different GATA1 mutations, although a minor TMD clone identical to the AMKL clone was present at birth. These observations suggest that a minor clone rather than the predominant clone at the time of TMD may give rise to AMKL later on.

本文言語英語
ページ(範囲)696-698
ページ数3
ジャーナルJournal of Pediatric Hematology/Oncology
28
10
DOI
出版ステータス出版済み - 10月 2006
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 血液学
  • 腫瘍学

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