Development of drug carrier responding to Matrix Metalloproteinase II

Kentaro Nishi, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

研究成果: 会議への寄与タイプ論文

抄録

Matrix Metalloproteinase II (MMP II) plays a key role when cancer cells perform invasion and metastasis by degrading a collagen. Moreover, the expression of this proteinase is enhanced in bone destruction in rheumatoid arthritis. We create a novel drug delivery system that can respond to MMP II. In our DDS, the micelle which is formed from amphiphilic copolymers is used as a drug carrier. The copolymer is composed of hydrophobic polymer main chain and hydrophilic polyethylene glycol side chain which is linked to the main chain with substrate of MMP II. The micelle will be coagulated by digestion of the substrate by MMP II that is enhanced in cancer invasion and rheumatoid and will release the incorporated drug. To realize the DDS, we synthesized the copolymers and studied their physicochemical properties.

元の言語英語
ページ数1
出版物ステータス出版済み - 10 19 2006
イベント55th SPSJ Annual Meeting - Nagoya, 日本
継続期間: 5 24 20065 26 2006

その他

その他55th SPSJ Annual Meeting
日本
Nagoya
期間5/24/065/26/06

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Copolymers
Micelles
Substrates
Collagen
Polyethylene glycols
Bone
Cells
Metalloproteases
Polymers
Peptide Hydrolases
Drug Delivery Systems

All Science Journal Classification (ASJC) codes

  • Engineering(all)

これを引用

Nishi, K., Mori, T., Niidome, T., & Katayama, Y. (2006). Development of drug carrier responding to Matrix Metalloproteinase II. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.

Development of drug carrier responding to Matrix Metalloproteinase II. / Nishi, Kentaro; Mori, Takeshi; Niidome, Takuro; Katayama, Yoshiki.

2006. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.

研究成果: 会議への寄与タイプ論文

Nishi, K, Mori, T, Niidome, T & Katayama, Y 2006, 'Development of drug carrier responding to Matrix Metalloproteinase II', 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本, 5/24/06 - 5/26/06.
Nishi K, Mori T, Niidome T, Katayama Y. Development of drug carrier responding to Matrix Metalloproteinase II. 2006. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.
Nishi, Kentaro ; Mori, Takeshi ; Niidome, Takuro ; Katayama, Yoshiki. / Development of drug carrier responding to Matrix Metalloproteinase II. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.1 p.
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