TY - JOUR
T1 - Development of esophageal cancer after endoscopic injection sclerotherapy for esophageal varices
T2 - Three case reports
AU - Ohta, M.
AU - Kuwano, H.
AU - Hashizume, M.
AU - Sonoda, T.
AU - Tomikawa, M.
AU - Higashi, H.
AU - Ohno, S.
AU - Watanabe, M.
AU - Sugimachi, K.
PY - 1995
Y1 - 1995
N2 - We report here three cases of squamous-cell carcinoma of the esophagus following endoscopic injection sclerotherapy for esophageal varices. All three patients were men and cigarette smokers, with a mean age of 58.3 ± 5.0 years. Hepatitis B and C virus infection tests were negative, and alcoholic cirrhosis was present in each patient. The interval between sclerotherapy and the development of carcinoma was 9, 10, and 33 months, in the respective cases. The sclerosant used was 5% ethanolamine oleate with a mean total volume of 51.0 ± 18.9 ml. While we have no evidence of a direct relationship between sclerotherapy and esophageal cancer, in patients with alcoholic cirrhosis who have risk factors for esophageal cancer there may be an acceleration of the potential malignancy, as a result of the chronic inflammation related to sclerotherapy. Such patients should be closely followed, using endoscopy.
AB - We report here three cases of squamous-cell carcinoma of the esophagus following endoscopic injection sclerotherapy for esophageal varices. All three patients were men and cigarette smokers, with a mean age of 58.3 ± 5.0 years. Hepatitis B and C virus infection tests were negative, and alcoholic cirrhosis was present in each patient. The interval between sclerotherapy and the development of carcinoma was 9, 10, and 33 months, in the respective cases. The sclerosant used was 5% ethanolamine oleate with a mean total volume of 51.0 ± 18.9 ml. While we have no evidence of a direct relationship between sclerotherapy and esophageal cancer, in patients with alcoholic cirrhosis who have risk factors for esophageal cancer there may be an acceleration of the potential malignancy, as a result of the chronic inflammation related to sclerotherapy. Such patients should be closely followed, using endoscopy.
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U2 - 10.1055/s-2007-1005742
DO - 10.1055/s-2007-1005742
M3 - Article
C2 - 8549446
AN - SCOPUS:0029132682
VL - 27
SP - 455
EP - 458
JO - Endoscopy
JF - Endoscopy
SN - 0013-726X
IS - 6
ER -