抄録
Glycosaminoglycans (GAGs) are polysaccharides found in living systems that have key biological roles and function as polyelectrolytes owing to their large number of sulfate groups. There have been many reports describing the syntheses of GAGs and the development of GAG mimetics and analogs. The preparation of such GAG mimics has utilized versatile methods ranging from total syntheses to synthetic polymer chemistry approaches. The core of GAG mimetic production is the fusion of complex chemical structures with polymeric properties. Multivalent interactions of the saccharides with specific biological targets, such as proteins, are an essential function of GAGs and other multivalent saccharides. In this review, methods for generating GAGs from glycopolymers are presented and research reports describing the functional characterization of the synthesized GAGs are outlined.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 229-237 |
| ページ数 | 9 |
| ジャーナル | Polymer Journal |
| 巻 | 48 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 3 1 2016 |
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All Science Journal Classification (ASJC) codes
- Polymers and Plastics
- Materials Chemistry
これを引用
Development of glycosaminoglycan mimetics using glycopolymers. / Miura, Yoshiko; Fukuda, Tomohiro; Seto, Hirokazu; Hoshino, Yu.
：: Polymer Journal, 巻 48, 番号 3, 01.03.2016, p. 229-237.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Development of glycosaminoglycan mimetics using glycopolymers
AU - Miura, Yoshiko
AU - Fukuda, Tomohiro
AU - Seto, Hirokazu
AU - Hoshino, Yu
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Glycosaminoglycans (GAGs) are polysaccharides found in living systems that have key biological roles and function as polyelectrolytes owing to their large number of sulfate groups. There have been many reports describing the syntheses of GAGs and the development of GAG mimetics and analogs. The preparation of such GAG mimics has utilized versatile methods ranging from total syntheses to synthetic polymer chemistry approaches. The core of GAG mimetic production is the fusion of complex chemical structures with polymeric properties. Multivalent interactions of the saccharides with specific biological targets, such as proteins, are an essential function of GAGs and other multivalent saccharides. In this review, methods for generating GAGs from glycopolymers are presented and research reports describing the functional characterization of the synthesized GAGs are outlined.
AB - Glycosaminoglycans (GAGs) are polysaccharides found in living systems that have key biological roles and function as polyelectrolytes owing to their large number of sulfate groups. There have been many reports describing the syntheses of GAGs and the development of GAG mimetics and analogs. The preparation of such GAG mimics has utilized versatile methods ranging from total syntheses to synthetic polymer chemistry approaches. The core of GAG mimetic production is the fusion of complex chemical structures with polymeric properties. Multivalent interactions of the saccharides with specific biological targets, such as proteins, are an essential function of GAGs and other multivalent saccharides. In this review, methods for generating GAGs from glycopolymers are presented and research reports describing the functional characterization of the synthesized GAGs are outlined.
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UR - http://www.scopus.com/inward/citedby.url?scp=84960106608&partnerID=8YFLogxK
U2 - 10.1038/pj.2015.110
DO - 10.1038/pj.2015.110
M3 - Review article
AN - SCOPUS:84960106608
VL - 48
SP - 229
EP - 237
JO - Polymer Journal
JF - Polymer Journal
SN - 0032-3896
IS - 3
ER -