Development of glycosaminoglycan mimetics using glycopolymers

Yoshiko Miura, Tomohiro Fukuda, Hirokazu Seto, Yu Hoshino

研究成果: ジャーナルへの寄稿評論記事

12 引用 (Scopus)

抄録

Glycosaminoglycans (GAGs) are polysaccharides found in living systems that have key biological roles and function as polyelectrolytes owing to their large number of sulfate groups. There have been many reports describing the syntheses of GAGs and the development of GAG mimetics and analogs. The preparation of such GAG mimics has utilized versatile methods ranging from total syntheses to synthetic polymer chemistry approaches. The core of GAG mimetic production is the fusion of complex chemical structures with polymeric properties. Multivalent interactions of the saccharides with specific biological targets, such as proteins, are an essential function of GAGs and other multivalent saccharides. In this review, methods for generating GAGs from glycopolymers are presented and research reports describing the functional characterization of the synthesized GAGs are outlined.

元の言語英語
ページ(範囲)229-237
ページ数9
ジャーナルPolymer Journal
48
発行部数3
DOI
出版物ステータス出版済み - 3 1 2016

Fingerprint

Glycosaminoglycans
Polysaccharides
Polyelectrolytes
Sulfates
Polymers
Fusion reactions
Proteins

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Materials Chemistry

これを引用

Development of glycosaminoglycan mimetics using glycopolymers. / Miura, Yoshiko; Fukuda, Tomohiro; Seto, Hirokazu; Hoshino, Yu.

:: Polymer Journal, 巻 48, 番号 3, 01.03.2016, p. 229-237.

研究成果: ジャーナルへの寄稿評論記事

Miura, Yoshiko ; Fukuda, Tomohiro ; Seto, Hirokazu ; Hoshino, Yu. / Development of glycosaminoglycan mimetics using glycopolymers. :: Polymer Journal. 2016 ; 巻 48, 番号 3. pp. 229-237.
@article{0f605f09d21c46e0a71810305c42fd57,
title = "Development of glycosaminoglycan mimetics using glycopolymers",
abstract = "Glycosaminoglycans (GAGs) are polysaccharides found in living systems that have key biological roles and function as polyelectrolytes owing to their large number of sulfate groups. There have been many reports describing the syntheses of GAGs and the development of GAG mimetics and analogs. The preparation of such GAG mimics has utilized versatile methods ranging from total syntheses to synthetic polymer chemistry approaches. The core of GAG mimetic production is the fusion of complex chemical structures with polymeric properties. Multivalent interactions of the saccharides with specific biological targets, such as proteins, are an essential function of GAGs and other multivalent saccharides. In this review, methods for generating GAGs from glycopolymers are presented and research reports describing the functional characterization of the synthesized GAGs are outlined.",
author = "Yoshiko Miura and Tomohiro Fukuda and Hirokazu Seto and Yu Hoshino",
year = "2016",
month = "3",
day = "1",
doi = "10.1038/pj.2015.110",
language = "English",
volume = "48",
pages = "229--237",
journal = "Polymer Journal",
issn = "0032-3896",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Development of glycosaminoglycan mimetics using glycopolymers

AU - Miura, Yoshiko

AU - Fukuda, Tomohiro

AU - Seto, Hirokazu

AU - Hoshino, Yu

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Glycosaminoglycans (GAGs) are polysaccharides found in living systems that have key biological roles and function as polyelectrolytes owing to their large number of sulfate groups. There have been many reports describing the syntheses of GAGs and the development of GAG mimetics and analogs. The preparation of such GAG mimics has utilized versatile methods ranging from total syntheses to synthetic polymer chemistry approaches. The core of GAG mimetic production is the fusion of complex chemical structures with polymeric properties. Multivalent interactions of the saccharides with specific biological targets, such as proteins, are an essential function of GAGs and other multivalent saccharides. In this review, methods for generating GAGs from glycopolymers are presented and research reports describing the functional characterization of the synthesized GAGs are outlined.

AB - Glycosaminoglycans (GAGs) are polysaccharides found in living systems that have key biological roles and function as polyelectrolytes owing to their large number of sulfate groups. There have been many reports describing the syntheses of GAGs and the development of GAG mimetics and analogs. The preparation of such GAG mimics has utilized versatile methods ranging from total syntheses to synthetic polymer chemistry approaches. The core of GAG mimetic production is the fusion of complex chemical structures with polymeric properties. Multivalent interactions of the saccharides with specific biological targets, such as proteins, are an essential function of GAGs and other multivalent saccharides. In this review, methods for generating GAGs from glycopolymers are presented and research reports describing the functional characterization of the synthesized GAGs are outlined.

UR - http://www.scopus.com/inward/record.url?scp=84960106608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960106608&partnerID=8YFLogxK

U2 - 10.1038/pj.2015.110

DO - 10.1038/pj.2015.110

M3 - Review article

AN - SCOPUS:84960106608

VL - 48

SP - 229

EP - 237

JO - Polymer Journal

JF - Polymer Journal

SN - 0032-3896

IS - 3

ER -