TY - JOUR
T1 - [Development of hemostatic sealant for arterial anastomosis; clinical application].
AU - Morita, Shigeki
AU - Matsuda, Takehisa
AU - Eto, Masataka
AU - Oda, Shinichiro
AU - Tominaga, Ryuji
PY - 2013/5
Y1 - 2013/5
N2 - For the purpose of examining the clinical applicability of a newly developed surgical sealant, animal experiments were performed, and clinical trial was followed. In animal experiments, several animal models, including carotid artery anastomosis model and coronary artery bypass grafting model were undertaken. In each model, complete hemostasis of the anastomoses using four simple interrupted sutures, was obtained. In addition, elastomeric property of the sealant prevented thinning of the arterial wall. The clinical trial performed in patients with thoracic aortic surgery showed significantly better hemostasis even under heparinized condition. Based on these excellent results, clinical usage of the sealant was approved.
AB - For the purpose of examining the clinical applicability of a newly developed surgical sealant, animal experiments were performed, and clinical trial was followed. In animal experiments, several animal models, including carotid artery anastomosis model and coronary artery bypass grafting model were undertaken. In each model, complete hemostasis of the anastomoses using four simple interrupted sutures, was obtained. In addition, elastomeric property of the sealant prevented thinning of the arterial wall. The clinical trial performed in patients with thoracic aortic surgery showed significantly better hemostasis even under heparinized condition. Based on these excellent results, clinical usage of the sealant was approved.
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M3 - Article
C2 - 23674039
AN - SCOPUS:84891693518
VL - 66
SP - 395
EP - 400
JO - Japanese Journal of Thoracic Surgery
JF - Japanese Journal of Thoracic Surgery
SN - 0021-5252
IS - 5
ER -