Development of holistic cancer treatment centering cancer patients-from the standpoint of hypoxia and hedgehog signaling

Hideya Ohnishi, Toshitatsu Ogino, Takashi Morisaki, Mitsuo Katano

研究成果: ジャーナルへの寄稿記事

抄録

Recently, hypoxia that is one of cancer microenvironments, takes much attention. Because circumstance that we usually perform experiment is 20% 02 condition, it is likely that different signaling pathways may be activated in vivo cancer. We focused Hedgehog (Hh) signaling as one of activated pathways under hypoxia. It has been shown that Hh signaling is activated under hypoxia, followed by inducing malignant phenotypes in pancreatic cancer. Therefore, Hh signaling inhibitor should elicit anti-tumor effect. However, if we consider "whole-person therapy" we should confirm how Hh signaling affects the function of immune cells. In the present study, we describe hypoxia/Hh signaling/functions of cancer cells and immune cells focusing our previous results.

元の言語英語
ページ(範囲)977-980
ページ数4
ジャーナルJapanese Journal of Cancer and Chemotherapy
44
発行部数11
出版物ステータス出版済み - 11 1 2017

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Neoplasms
Tumor Microenvironment
Therapeutics
Pancreatic Neoplasms
Phenotype
Hypoxia

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Development of holistic cancer treatment centering cancer patients-from the standpoint of hypoxia and hedgehog signaling. / Ohnishi, Hideya; Ogino, Toshitatsu; Morisaki, Takashi; Katano, Mitsuo.

:: Japanese Journal of Cancer and Chemotherapy, 巻 44, 番号 11, 01.11.2017, p. 977-980.

研究成果: ジャーナルへの寄稿記事

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