Development of Immunity against Listeria monocytogenes in athymic Nude versus neonatally thymectomized mice

Kikuo Nomoto, Yoshinori Shimamoto, Kazuto Taniguchi, Chiharu Kubo, Hideyuki Kawauchi, Masao Mitsuyama, Kenji Takeya

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

抄録

The thymus requirement for the development of immunological responsiveness was determined by estimation of immune responses raised to Listeria monocytogenes in athymic nude, neonatally thymectomized, and sham-operated mice at 6 weeks of age. Not only sham-operated mice, but also neonatally thymectomized mice could completely eliminate the bacteria from the spleen and liver, while athymic nude mice could not eliminate them and showed a persistent form of infection. A strong delayed footpad reaction and acquired cellular resistance could be raised in neonatally thymectomized mice just as well as in sham-operated mice, but not in athymic nude mice. The delayed footpad reaction could be induced in neonatally thymectomized mice without an accompanying ability to inhibit macrophage migration. These results suggest that T cells responsible for immunity against listerial infection require the presence of the thymus for only a very short period in their development.

元の言語英語
ページ(範囲)134-143
ページ数10
ジャーナルCellular Immunology
75
発行部数1
DOI
出版物ステータス出版済み - 1 1983

Fingerprint

Listeria monocytogenes
Immunity
Nude Mice
Thymus Gland
Infection
Spleen
Macrophages
Bacteria
T-Lymphocytes
Liver

All Science Journal Classification (ASJC) codes

  • Immunology

これを引用

Development of Immunity against Listeria monocytogenes in athymic Nude versus neonatally thymectomized mice. / Nomoto, Kikuo; Shimamoto, Yoshinori; Taniguchi, Kazuto; Kubo, Chiharu; Kawauchi, Hideyuki; Mitsuyama, Masao; Takeya, Kenji.

:: Cellular Immunology, 巻 75, 番号 1, 01.1983, p. 134-143.

研究成果: ジャーナルへの寄稿記事

Nomoto, K, Shimamoto, Y, Taniguchi, K, Kubo, C, Kawauchi, H, Mitsuyama, M & Takeya, K 1983, 'Development of Immunity against Listeria monocytogenes in athymic Nude versus neonatally thymectomized mice', Cellular Immunology, 巻. 75, 番号 1, pp. 134-143. https://doi.org/10.1016/0008-8749(83)90312-X
Nomoto, Kikuo ; Shimamoto, Yoshinori ; Taniguchi, Kazuto ; Kubo, Chiharu ; Kawauchi, Hideyuki ; Mitsuyama, Masao ; Takeya, Kenji. / Development of Immunity against Listeria monocytogenes in athymic Nude versus neonatally thymectomized mice. :: Cellular Immunology. 1983 ; 巻 75, 番号 1. pp. 134-143.
@article{1161eba044a0494a841cffc2de87427b,
title = "Development of Immunity against Listeria monocytogenes in athymic Nude versus neonatally thymectomized mice",
abstract = "The thymus requirement for the development of immunological responsiveness was determined by estimation of immune responses raised to Listeria monocytogenes in athymic nude, neonatally thymectomized, and sham-operated mice at 6 weeks of age. Not only sham-operated mice, but also neonatally thymectomized mice could completely eliminate the bacteria from the spleen and liver, while athymic nude mice could not eliminate them and showed a persistent form of infection. A strong delayed footpad reaction and acquired cellular resistance could be raised in neonatally thymectomized mice just as well as in sham-operated mice, but not in athymic nude mice. The delayed footpad reaction could be induced in neonatally thymectomized mice without an accompanying ability to inhibit macrophage migration. These results suggest that T cells responsible for immunity against listerial infection require the presence of the thymus for only a very short period in their development.",
author = "Kikuo Nomoto and Yoshinori Shimamoto and Kazuto Taniguchi and Chiharu Kubo and Hideyuki Kawauchi and Masao Mitsuyama and Kenji Takeya",
year = "1983",
month = "1",
doi = "10.1016/0008-8749(83)90312-X",
language = "English",
volume = "75",
pages = "134--143",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Development of Immunity against Listeria monocytogenes in athymic Nude versus neonatally thymectomized mice

AU - Nomoto, Kikuo

AU - Shimamoto, Yoshinori

AU - Taniguchi, Kazuto

AU - Kubo, Chiharu

AU - Kawauchi, Hideyuki

AU - Mitsuyama, Masao

AU - Takeya, Kenji

PY - 1983/1

Y1 - 1983/1

N2 - The thymus requirement for the development of immunological responsiveness was determined by estimation of immune responses raised to Listeria monocytogenes in athymic nude, neonatally thymectomized, and sham-operated mice at 6 weeks of age. Not only sham-operated mice, but also neonatally thymectomized mice could completely eliminate the bacteria from the spleen and liver, while athymic nude mice could not eliminate them and showed a persistent form of infection. A strong delayed footpad reaction and acquired cellular resistance could be raised in neonatally thymectomized mice just as well as in sham-operated mice, but not in athymic nude mice. The delayed footpad reaction could be induced in neonatally thymectomized mice without an accompanying ability to inhibit macrophage migration. These results suggest that T cells responsible for immunity against listerial infection require the presence of the thymus for only a very short period in their development.

AB - The thymus requirement for the development of immunological responsiveness was determined by estimation of immune responses raised to Listeria monocytogenes in athymic nude, neonatally thymectomized, and sham-operated mice at 6 weeks of age. Not only sham-operated mice, but also neonatally thymectomized mice could completely eliminate the bacteria from the spleen and liver, while athymic nude mice could not eliminate them and showed a persistent form of infection. A strong delayed footpad reaction and acquired cellular resistance could be raised in neonatally thymectomized mice just as well as in sham-operated mice, but not in athymic nude mice. The delayed footpad reaction could be induced in neonatally thymectomized mice without an accompanying ability to inhibit macrophage migration. These results suggest that T cells responsible for immunity against listerial infection require the presence of the thymus for only a very short period in their development.

UR - http://www.scopus.com/inward/record.url?scp=0020700621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020700621&partnerID=8YFLogxK

U2 - 10.1016/0008-8749(83)90312-X

DO - 10.1016/0008-8749(83)90312-X

M3 - Article

C2 - 6825182

AN - SCOPUS:0020700621

VL - 75

SP - 134

EP - 143

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 1

ER -