TY - JOUR
T1 - Development of Immunity against Listeria monocytogenes in athymic Nude versus neonatally thymectomized mice
AU - Nomoto, Kikuo
AU - Shimamoto, Yoshinori
AU - Taniguchi, Kazuto
AU - Kubo, Chiharu
AU - Kawauchi, Hideyuki
AU - Mitsuyama, Masao
AU - Takeya, Kenji
N1 - Funding Information:
was supported by a grant-in-aid for scientific research from the Ministry of Education, Japan, and a grant-in-aid for cancer research from the Ministry of Health and Welfare,
PY - 1983/1
Y1 - 1983/1
N2 - The thymus requirement for the development of immunological responsiveness was determined by estimation of immune responses raised to Listeria monocytogenes in athymic nude, neonatally thymectomized, and sham-operated mice at 6 weeks of age. Not only sham-operated mice, but also neonatally thymectomized mice could completely eliminate the bacteria from the spleen and liver, while athymic nude mice could not eliminate them and showed a persistent form of infection. A strong delayed footpad reaction and acquired cellular resistance could be raised in neonatally thymectomized mice just as well as in sham-operated mice, but not in athymic nude mice. The delayed footpad reaction could be induced in neonatally thymectomized mice without an accompanying ability to inhibit macrophage migration. These results suggest that T cells responsible for immunity against listerial infection require the presence of the thymus for only a very short period in their development.
AB - The thymus requirement for the development of immunological responsiveness was determined by estimation of immune responses raised to Listeria monocytogenes in athymic nude, neonatally thymectomized, and sham-operated mice at 6 weeks of age. Not only sham-operated mice, but also neonatally thymectomized mice could completely eliminate the bacteria from the spleen and liver, while athymic nude mice could not eliminate them and showed a persistent form of infection. A strong delayed footpad reaction and acquired cellular resistance could be raised in neonatally thymectomized mice just as well as in sham-operated mice, but not in athymic nude mice. The delayed footpad reaction could be induced in neonatally thymectomized mice without an accompanying ability to inhibit macrophage migration. These results suggest that T cells responsible for immunity against listerial infection require the presence of the thymus for only a very short period in their development.
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U2 - 10.1016/0008-8749(83)90312-X
DO - 10.1016/0008-8749(83)90312-X
M3 - Article
C2 - 6825182
AN - SCOPUS:0020700621
SN - 0008-8749
VL - 75
SP - 134
EP - 143
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1
ER -