Development of new 1,3-diazaphenoxazine derivatives (thiog-grasp) to covalently capture 8-thioguanosine

Yasufumi Fuchi, Hideto Obayashi, Shigeki Sasaki

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (thioG-grasp). It was expected that the chlorine atom at the end of the linker would be displaced by the nucleophilic attack by the sulfur atom of 8-thioguanosine via multiple hydrogen-bonded complexes. The thioG-grasp derivative with a propyl linker reacted efficiently with 8-thioguanosine to form the corresponding adduct.

本文言語英語
ページ(範囲)1078-1087
ページ数10
ジャーナルMolecules
20
1
DOI
出版ステータス出版済み - 1月 1 2015

!!!All Science Journal Classification (ASJC) codes

  • 分析化学
  • 化学(その他)
  • 分子医療
  • 薬科学
  • 創薬
  • 物理化学および理論化学
  • 有機化学

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