MRI造影剤の影響を回避した新しい 血清カルシウム測定試薬の開発

Eisaku Hokazono, Tomota Nakano, Yuji Oguchi, Osawa Susumu

研究成果: ジャーナルへの寄稿記事

抄録

We previously reported a serum calcium measurement method using Chlorophosphonazo- III (CPZ-III). In this method, the reagent stability is higher than in conventional methods to react samples in an acid medium. High specificity to calcium is also achieved due to the addition of a surfac- tant to the reagent. However, gadolinium, which is used as a contrast agent for magnetic resonance imaging (MRI), causes a positive error in the measurement. Therefore, we have improved our previous method, and developed a new measurement reagent that is not affected by gadolinium. As a result, it was confirmed not to be unaffected by gadolinium to 2.0 mmol/L. Finally, even if our new method is employed just after using a contrast agent, the serum calcium tests should be unaffected. We expect this method to be used as a routine and emergency test in clinical laboratories because it is stable, accurate, and does not contain any heavy metals, dangerous materials, or mutagenic substances.
元の言語Japanese
ページ(範囲)191-197
ジャーナルJournal of Analytical Bio-Science
33
発行部数2
出版物ステータス出版済み - 3 2010

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gadolinium
serums
reagents
magnetic resonance
calcium
emergencies
heavy metals
surfactants
acids
causes

これを引用

MRI造影剤の影響を回避した新しい 血清カルシウム測定試薬の開発. / Hokazono, Eisaku; Nakano, Tomota; Oguchi, Yuji; Susumu, Osawa.

:: Journal of Analytical Bio-Science, 巻 33, 番号 2, 03.2010, p. 191-197.

研究成果: ジャーナルへの寄稿記事

Hokazono, Eisaku ; Nakano, Tomota ; Oguchi, Yuji ; Susumu, Osawa. / MRI造影剤の影響を回避した新しい 血清カルシウム測定試薬の開発. :: Journal of Analytical Bio-Science. 2010 ; 巻 33, 番号 2. pp. 191-197.
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abstract = "We previously reported a serum calcium measurement method using Chlorophosphonazo- III (CPZ-III). In this method, the reagent stability is higher than in conventional methods to react samples in an acid medium. High specificity to calcium is also achieved due to the addition of a surfac- tant to the reagent. However, gadolinium, which is used as a contrast agent for magnetic resonance imaging (MRI), causes a positive error in the measurement. Therefore, we have improved our previous method, and developed a new measurement reagent that is not affected by gadolinium. As a result, it was confirmed not to be unaffected by gadolinium to 2.0 mmol/L. Finally, even if our new method is employed just after using a contrast agent, the serum calcium tests should be unaffected. We expect this method to be used as a routine and emergency test in clinical laboratories because it is stable, accurate, and does not contain any heavy metals, dangerous materials, or mutagenic substances.",
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