Development of novel functional molecules targeting DNA and RNA

Shigeki Sasaki

研究成果: Contribution to journalReview article査読

抄録

Nucleic acid therapeutics such as antisense and small interfering RNA (siRNA) have attracted increasing attention as innovative medicines that interfere with and/or modify gene expression systems. We have developed new functional oligonucleotides that can target DNA and RNA with high efficiency and selectivity. This review summarizes our achievements, including (1) the formation of non-natural triplex DNA for sequence-specific inhibition of transcription; (2) artificial receptor molecules for 8-oxidized-guanosine nucleosides; and (3) reactive oligonucleotides with a cross-linking agent or a functionality-transfer nucleoside for RNA pinpoint modification.

本文言語英語
ページ(範囲)505-518
ページ数14
ジャーナルChemical and Pharmaceutical Bulletin
67
6
DOI
出版ステータス出版済み - 2019

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 創薬

フィンガープリント

「Development of novel functional molecules targeting DNA and RNA」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル