Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction

Kenjiro Ikuta, Takeshi Mori, Tatsurhiro Yamamoto, Takuro Niidome, Hiroaki Shimokawa, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

The vascular endothelium plays an important role in regulating vascular homeostasis. Damage to the endothelium can lead to cardiovascular diseases such as arteriosclerosis. Therefore, early-stage detection and evaluation of vascular endothelium dysfunction would be very important for effective diagnosis and therapy. We synthesized a polymeric drug carrier bearing an Evans blue analogue as a probing unit for endothelium injury. The polymeric carrier spontaneously formed stable nanoparticles with micelle-like structure in aqueous media and could encapsulate hydrophobic doxorubicin (DOX). The encapsulated DOX showed a sustainable release profile over a period of 10-60 h depending on the loaded DOX concentration. The polymeric carrier specifically adsorbed against the endothelium-injured site in extracted porcine aorta. These properties of the polymeric drug carrier will be suitable for specific drug delivery to endothelium dysfunctional region.

元の言語英語
ページ(範囲)2811-2818
ページ数8
ジャーナルBioorganic and Medicinal Chemistry
16
発行部数6
DOI
出版物ステータス出版済み - 3 15 2008

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Drug Delivery Systems
Doxorubicin
Endothelium
Blood Vessels
Drug Carriers
Vascular Endothelium
Bearings (structural)
Evans Blue
Micelles
Drug delivery
Arteriosclerosis
Nanoparticles
Aorta
Homeostasis
Cardiovascular Diseases
Swine
Wounds and Injuries
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

これを引用

Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction. / Ikuta, Kenjiro; Mori, Takeshi; Yamamoto, Tatsurhiro; Niidome, Takuro; Shimokawa, Hiroaki; Katayama, Yoshiki.

:: Bioorganic and Medicinal Chemistry, 巻 16, 番号 6, 15.03.2008, p. 2811-2818.

研究成果: ジャーナルへの寄稿記事

Ikuta, Kenjiro ; Mori, Takeshi ; Yamamoto, Tatsurhiro ; Niidome, Takuro ; Shimokawa, Hiroaki ; Katayama, Yoshiki. / Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction. :: Bioorganic and Medicinal Chemistry. 2008 ; 巻 16, 番号 6. pp. 2811-2818.
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