抄録
Enterococcus spp. can cause illnesses such as bacteremia, endocarditis, urinary tract infections, posttreatment endophthalmitis, and endodontic infections (Murray 2000; Marothi et al. 2005). Medical treatment of these infectious diseases depends largely on bactericidal or bacteriostatic antibiotics. However, frequent use of such antibiotics has led to the development of drug-resistant bacterial strains, which are difficult to treat (Marothi et al. 2005; Murray 2000). As a result, the blockage of bacterial quorum-sensing (QS) systems has attracted attention owing to its potential to attenuate bacterial virulence without inducing bactericidal pressures that lead to drug resistance. This approach, called quorum quenching (QQ), can be undertaken partially or completely independently of antibiotic treatment. Among several QQ strategies, the use of QS inhibitors (QSIs), which are small molecules that have no adverse effects on bacteria, offers advantages in terms of drug delivery and decreased damage to commensal microbiota.
| 元の言語 | 英語 |
|---|---|
| ホスト出版物のタイトル | Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight |
| 出版者 | Springer India |
| ページ | 319-326 |
| ページ数 | 8 |
| ISBN（電子版） | 9788132219828 |
| ISBN（印刷物） | 9788132219811 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 2015 |
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All Science Journal Classification (ASJC) codes
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
- Immunology and Microbiology(all)
これを引用
Development of quorum-sensing inhibitors targeting the fsr system of enterococcus faecalis. / Singh, Ravindra Pal; Nakayama, Jiro.
Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight. Springer India, 2015. p. 319-326.研究成果: 著書/レポートタイプへの貢献 › 章
}
TY - CHAP
T1 - Development of quorum-sensing inhibitors targeting the fsr system of enterococcus faecalis
AU - Singh, Ravindra Pal
AU - Nakayama, Jiro
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Enterococcus spp. can cause illnesses such as bacteremia, endocarditis, urinary tract infections, posttreatment endophthalmitis, and endodontic infections (Murray 2000; Marothi et al. 2005). Medical treatment of these infectious diseases depends largely on bactericidal or bacteriostatic antibiotics. However, frequent use of such antibiotics has led to the development of drug-resistant bacterial strains, which are difficult to treat (Marothi et al. 2005; Murray 2000). As a result, the blockage of bacterial quorum-sensing (QS) systems has attracted attention owing to its potential to attenuate bacterial virulence without inducing bactericidal pressures that lead to drug resistance. This approach, called quorum quenching (QQ), can be undertaken partially or completely independently of antibiotic treatment. Among several QQ strategies, the use of QS inhibitors (QSIs), which are small molecules that have no adverse effects on bacteria, offers advantages in terms of drug delivery and decreased damage to commensal microbiota.
AB - Enterococcus spp. can cause illnesses such as bacteremia, endocarditis, urinary tract infections, posttreatment endophthalmitis, and endodontic infections (Murray 2000; Marothi et al. 2005). Medical treatment of these infectious diseases depends largely on bactericidal or bacteriostatic antibiotics. However, frequent use of such antibiotics has led to the development of drug-resistant bacterial strains, which are difficult to treat (Marothi et al. 2005; Murray 2000). As a result, the blockage of bacterial quorum-sensing (QS) systems has attracted attention owing to its potential to attenuate bacterial virulence without inducing bactericidal pressures that lead to drug resistance. This approach, called quorum quenching (QQ), can be undertaken partially or completely independently of antibiotic treatment. Among several QQ strategies, the use of QS inhibitors (QSIs), which are small molecules that have no adverse effects on bacteria, offers advantages in terms of drug delivery and decreased damage to commensal microbiota.
UR - http://www.scopus.com/inward/record.url?scp=84943388543&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943388543&partnerID=8YFLogxK
U2 - 10.1007/978-81-322-1982-8__25
DO - 10.1007/978-81-322-1982-8__25
M3 - Chapter
SN - 9788132219811
SP - 319
EP - 326
BT - Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight
PB - Springer India
ER -