抄録
Enterococcus spp. can cause illnesses such as bacteremia, endocarditis, urinary tract infections, posttreatment endophthalmitis, and endodontic infections (Murray 2000; Marothi et al. 2005). Medical treatment of these infectious diseases depends largely on bactericidal or bacteriostatic antibiotics. However, frequent use of such antibiotics has led to the development of drug-resistant bacterial strains, which are difficult to treat (Marothi et al. 2005; Murray 2000). As a result, the blockage of bacterial quorum-sensing (QS) systems has attracted attention owing to its potential to attenuate bacterial virulence without inducing bactericidal pressures that lead to drug resistance. This approach, called quorum quenching (QQ), can be undertaken partially or completely independently of antibiotic treatment. Among several QQ strategies, the use of QS inhibitors (QSIs), which are small molecules that have no adverse effects on bacteria, offers advantages in terms of drug delivery and decreased damage to commensal microbiota.
本文言語 | 英語 |
---|---|
ホスト出版物のタイトル | Quorum Sensing vs Quorum Quenching |
ホスト出版物のサブタイトル | A Battle with no end in Sight |
出版社 | Springer India |
ページ | 319-326 |
ページ数 | 8 |
ISBN(電子版) | 9788132219828 |
ISBN(印刷版) | 9788132219811 |
DOI | |
出版ステータス | 出版済み - 1月 1 2015 |
!!!All Science Journal Classification (ASJC) codes
- 農業および生物科学(全般)
- 生化学、遺伝学、分子生物学(全般)
- 医学(全般)
- 免疫学および微生物学(全般)