TY - JOUR
T1 - Development of redox metabolic imaging using endogenous molecules
AU - Hyodo, Fuminori
AU - Ito, Shinji
AU - Eto, Hinako
AU - Nakaji, Tomoko
AU - Yasukawa, Keiji
AU - Kobayashi, Ryoma
AU - Utsumi, Hideo
N1 - Publisher Copyright:
© 2016 The Pharmaceutical Society of Japan.
PY - 2016
Y1 - 2016
N2 - Redox metabolism plays a central role in maintaining homeostasis in living organisms. The electron transfer system in mitochondria produces ATP via endogenous redox molecules such as flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), and coenzyme Q 10 (CoQ 10 ), which have flavin or quinone moieties. One-electron transfer reactions convert FMN, FAD, and CoQ 10 to the free radical intermediates FMNH and FADH, and CoQ 10 H, respectively. Dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) allows us to visualize free radicals in vitro and in vivo. We present a spectroscopic imaging technology with DNP-MRI, which enables the imaging of multiple free radical intermediates such as FADH and CoQH. DNP-MRI can also identify various endogenous free radical intermediates derived from redox transformations.
AB - Redox metabolism plays a central role in maintaining homeostasis in living organisms. The electron transfer system in mitochondria produces ATP via endogenous redox molecules such as flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), and coenzyme Q 10 (CoQ 10 ), which have flavin or quinone moieties. One-electron transfer reactions convert FMN, FAD, and CoQ 10 to the free radical intermediates FMNH and FADH, and CoQ 10 H, respectively. Dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) allows us to visualize free radicals in vitro and in vivo. We present a spectroscopic imaging technology with DNP-MRI, which enables the imaging of multiple free radical intermediates such as FADH and CoQH. DNP-MRI can also identify various endogenous free radical intermediates derived from redox transformations.
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U2 - 10.1248/yakushi.15-00234-6
DO - 10.1248/yakushi.15-00234-6
M3 - Review article
C2 - 27477725
AN - SCOPUS:84980347826
VL - 136
SP - 1107
EP - 1114
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 8
ER -