Development of the selective adsorbent for EDA containing fibronectin using heparin immobilized cellulose

Keiichi Miyashita, Eiji Sakashita, Keiichi Miyamoto, Masayuki Tokita, Takashi Komai

研究成果: ジャーナルへの寄稿学術誌査読

12 被引用数 (Scopus)

抄録

We have noticed that extra domain A containing fibronectin (EDA(+)FN) is closely related to inflammatory diseases and accordingly investigated a selective adsorbent to remove EDA(+)FN, which may increase the severity of the symptoms, from the plasma of rheumatoid arthritis (RA) patients. Three types of heparin immobilized cellulose (HC) were prepared and their adsorptive properties were evaluated by batchwise adsorption tests. The results showed that EDA(+)FN was adsorbed more efficiently than total FN on HC. In particular HC in which heparin was immobilized to amino residue had an excellent capacity. The adsorption rates of EDA(+)FN, total FN and antithrombin-III were 89, 15 and 17% respectively. This adsorbent is extremely useful in selectively removing EDA(+)FN from plasma.

本文言語英語
ページ(範囲)91-95
ページ数5
ジャーナルInternational Journal of Biological Macromolecules
22
2
DOI
出版ステータス出版済み - 4月 1998
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 構造生物学
  • 生化学
  • 分子生物学
  • 経済学、計量経済学
  • エネルギー(全般)

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