[Development trends for therapeutic antibody].

Eishi Baba, Hitoshi Kusaba, Shuji Nakano

研究成果: Contribution to journalReview article査読

抄録

Recent developments for therapeutic antibody have provided new options for cancer treatments. Modification of antibody molecules pursuing improvement of binding efficacy for Fcgamma receptors and enabling efficient recycling of antibody have been performed. Novel constructs of antibody possessing multivalent specificity and conjugated agents have also been developed. Based on exploration of new class of target molecules for therapeutic antibody, antibodies enhancing anti-tumor immunity such as anti-CTLA-4 antibody have appeared. These advancements would achieve more effective and safer therapy for various kinds of cancers.

本文言語英語
ページ(範囲)2098-2103
ページ数6
ジャーナルNihon rinsho. Japanese journal of clinical medicine
70
12
出版ステータス出版済み - 12 2012

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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