Developmental elimination of ectopic projection sites for the transgenic OR gene that has lost zone specificity in the olfactory epithelium

Hiroko Nakatani, Shou Serizawa, Miho Nakajima, Takeshi Imai, Hitoshi Sakano

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

抄録

In rodents, olfactory receptor (OR) genes are expressed in one of four zones in the olfactory epithelium (OE), and olfactory sensory neurons (OSNs) expressing the same OR project their axons to a specific set of glomeruli on the olfactory bulb (OB). Using the yeast artificial chromosome (YAC) transgenic system, we have analysed the expression of the murine OR gene MOR29A of the MOR28 cluster located on chromosome 14. Although expression of the endogenous MOR29A was restricted to the most dorsomedial zone, the transgenic MOR29A (Tg MOR29A) was expressed in all four zones of the OB. When the OB of the transgenic mouse was analysed, the axons of the OSNs expressing Tg MOR29A were found to project not only to the dorsal side but also to the ventral side of the OB as well. The ectopic projection sites on the ventral side gradually disappear during postnatal development. Naris occlusion prevents this elimination, suggesting that odorant stimulation is involved in eliminating the ectopic projection sites.

元の言語英語
ページ(範囲)2425-2432
ページ数8
ジャーナルEuropean Journal of Neuroscience
18
発行部数9
DOI
出版物ステータス出版済み - 11 1 2003

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Odorant Receptors
Olfactory Mucosa
Olfactory Bulb
Olfactory Receptor Neurons
Genes
Axons
Yeast Artificial Chromosomes
Chromosomes, Human, Pair 14
Transgenic Mice
Rodentia

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Developmental elimination of ectopic projection sites for the transgenic OR gene that has lost zone specificity in the olfactory epithelium. / Nakatani, Hiroko; Serizawa, Shou; Nakajima, Miho; Imai, Takeshi; Sakano, Hitoshi.

:: European Journal of Neuroscience, 巻 18, 番号 9, 01.11.2003, p. 2425-2432.

研究成果: ジャーナルへの寄稿記事

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AU - Imai, Takeshi

AU - Sakano, Hitoshi

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