Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein

Dong Kug Choi, Takashi Ito, Fujiko Tsukahara, Momoki Hirai, Yoshiyuki Sakaki

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

抄録

Proteins with RNA recognition motifs (RRMs) participate in many aspects of RNA metabolism, and some of them are required for the accomplishment of normal development. The neuroblastoma apoptosis-related RNA binding protein (NAPOR) is an ELAV-type RNA-binding protein with three characteristic RNP2/RNP1-type RRMs, which we identified as a gene induced during apoptosis of neuroblastoma cells. Here we isolated and characterized the cDNA for mNapor, the mouse homolog of NAPOR. The mNapor encodes mRNA sharing striking homology with that of NAPOR, not only in its open reading frame (98.5%) but also in the 3'-untranslated region (80.1%), and is mapped to chromosome 2 A2-A3, a region syntenic to the human NAPOR locus. In situ hybridization analysis revealed that the expression pattern of mNapor is spatially and temporally coincident with the occurrence of programmed cell death, suggesting its involvement in the development of the central nervous system in which apoptosis plays a crucial role. (C) 1999 Elsevier Science B.V. All rights reserved.

元の言語英語
ページ(範囲)135-142
ページ数8
ジャーナルGene
237
発行部数1
DOI
出版物ステータス出版済み - 9 3 1999
外部発表Yes

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RNA-Binding Proteins
Neuroblastoma
Apoptosis
Chromosomes, Human, Pair 2
3' Untranslated Regions
varespladib methyl
Open Reading Frames
In Situ Hybridization
Cell Death
Central Nervous System
Complementary DNA
RNA
Messenger RNA
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

これを引用

Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein. / Choi, Dong Kug; Ito, Takashi; Tsukahara, Fujiko; Hirai, Momoki; Sakaki, Yoshiyuki.

:: Gene, 巻 237, 番号 1, 03.09.1999, p. 135-142.

研究成果: ジャーナルへの寄稿記事

Choi, Dong Kug ; Ito, Takashi ; Tsukahara, Fujiko ; Hirai, Momoki ; Sakaki, Yoshiyuki. / Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein. :: Gene. 1999 ; 巻 237, 番号 1. pp. 135-142.
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abstract = "Proteins with RNA recognition motifs (RRMs) participate in many aspects of RNA metabolism, and some of them are required for the accomplishment of normal development. The neuroblastoma apoptosis-related RNA binding protein (NAPOR) is an ELAV-type RNA-binding protein with three characteristic RNP2/RNP1-type RRMs, which we identified as a gene induced during apoptosis of neuroblastoma cells. Here we isolated and characterized the cDNA for mNapor, the mouse homolog of NAPOR. The mNapor encodes mRNA sharing striking homology with that of NAPOR, not only in its open reading frame (98.5{\%}) but also in the 3'-untranslated region (80.1{\%}), and is mapped to chromosome 2 A2-A3, a region syntenic to the human NAPOR locus. In situ hybridization analysis revealed that the expression pattern of mNapor is spatially and temporally coincident with the occurrence of programmed cell death, suggesting its involvement in the development of the central nervous system in which apoptosis plays a crucial role. (C) 1999 Elsevier Science B.V. All rights reserved.",
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AU - Hirai, Momoki

AU - Sakaki, Yoshiyuki

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N2 - Proteins with RNA recognition motifs (RRMs) participate in many aspects of RNA metabolism, and some of them are required for the accomplishment of normal development. The neuroblastoma apoptosis-related RNA binding protein (NAPOR) is an ELAV-type RNA-binding protein with three characteristic RNP2/RNP1-type RRMs, which we identified as a gene induced during apoptosis of neuroblastoma cells. Here we isolated and characterized the cDNA for mNapor, the mouse homolog of NAPOR. The mNapor encodes mRNA sharing striking homology with that of NAPOR, not only in its open reading frame (98.5%) but also in the 3'-untranslated region (80.1%), and is mapped to chromosome 2 A2-A3, a region syntenic to the human NAPOR locus. In situ hybridization analysis revealed that the expression pattern of mNapor is spatially and temporally coincident with the occurrence of programmed cell death, suggesting its involvement in the development of the central nervous system in which apoptosis plays a crucial role. (C) 1999 Elsevier Science B.V. All rights reserved.

AB - Proteins with RNA recognition motifs (RRMs) participate in many aspects of RNA metabolism, and some of them are required for the accomplishment of normal development. The neuroblastoma apoptosis-related RNA binding protein (NAPOR) is an ELAV-type RNA-binding protein with three characteristic RNP2/RNP1-type RRMs, which we identified as a gene induced during apoptosis of neuroblastoma cells. Here we isolated and characterized the cDNA for mNapor, the mouse homolog of NAPOR. The mNapor encodes mRNA sharing striking homology with that of NAPOR, not only in its open reading frame (98.5%) but also in the 3'-untranslated region (80.1%), and is mapped to chromosome 2 A2-A3, a region syntenic to the human NAPOR locus. In situ hybridization analysis revealed that the expression pattern of mNapor is spatially and temporally coincident with the occurrence of programmed cell death, suggesting its involvement in the development of the central nervous system in which apoptosis plays a crucial role. (C) 1999 Elsevier Science B.V. All rights reserved.

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