Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein

Dong Kug Choi, Takashi Ito, Fujiko Tsukahara, Momoki Hirai, Yoshiyuki Sakaki

研究成果: Contribution to journalArticle査読

40 被引用数 (Scopus)

抄録

Proteins with RNA recognition motifs (RRMs) participate in many aspects of RNA metabolism, and some of them are required for the accomplishment of normal development. The neuroblastoma apoptosis-related RNA binding protein (NAPOR) is an ELAV-type RNA-binding protein with three characteristic RNP2/RNP1-type RRMs, which we identified as a gene induced during apoptosis of neuroblastoma cells. Here we isolated and characterized the cDNA for mNapor, the mouse homolog of NAPOR. The mNapor encodes mRNA sharing striking homology with that of NAPOR, not only in its open reading frame (98.5%) but also in the 3'-untranslated region (80.1%), and is mapped to chromosome 2 A2-A3, a region syntenic to the human NAPOR locus. In situ hybridization analysis revealed that the expression pattern of mNapor is spatially and temporally coincident with the occurrence of programmed cell death, suggesting its involvement in the development of the central nervous system in which apoptosis plays a crucial role. (C) 1999 Elsevier Science B.V. All rights reserved.

本文言語英語
ページ(範囲)135-142
ページ数8
ジャーナルGene
237
1
DOI
出版ステータス出版済み - 9 3 1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 遺伝学

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