Diabetes Mellitus, A risk factor for Alzheimer's Disease

Yusaku Nakabeppu (編集者), Toshiharu Ninomiya (編集者)

研究成果: 著書/レポートタイプ著書

抄録

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.
元の言語英語
出版場所Singapore
出版者Springer
ページ数248
1128
ISBN(電子版)978-981-13-3540-2
ISBN(印刷物)978-981-13-3539-6
DOI
出版物ステータス出版済み - 5 7 2019

出版物シリーズ

名前Advances in Experimental Medicine and Biology

Fingerprint

Diabetes Mellitus
Alzheimer Disease
Insulin
Glucose
Vascular Dementia
Brain
Dementia
Insulin Resistance
Biomarkers
Maintenance
Pathology
Proteins

これを引用

Nakabeppu, Y., & Ninomiya, T. (版) (2019). Diabetes Mellitus, A risk factor for Alzheimer's Disease. (Advances in Experimental Medicine and Biology). Singapore: Springer. https://doi.org/10.1007/978-981-13-3540-2

Diabetes Mellitus, A risk factor for Alzheimer's Disease. / Nakabeppu, Yusaku (編集者); Ninomiya, Toshiharu (編集者).

Singapore : Springer, 2019. 248 p. (Advances in Experimental Medicine and Biology).

研究成果: 著書/レポートタイプ著書

Nakabeppu, Y & Ninomiya, T (版) 2019, Diabetes Mellitus, A risk factor for Alzheimer's Disease. Advances in Experimental Medicine and Biology, 巻. 1128, Springer, Singapore. https://doi.org/10.1007/978-981-13-3540-2
Nakabeppu, Yusaku (編集者) ; Ninomiya, Toshiharu (編集者). / Diabetes Mellitus, A risk factor for Alzheimer's Disease. Singapore : Springer, 2019. 248 p. (Advances in Experimental Medicine and Biology).
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