Diacetone-glucose architecture as a chirality template. Part 9. Enantioselectiye synthesis of (R)-mevalonolactone and (R)-[2H9]mevalonolactone on carbohydrate template

Masashi Kishida, Noriaki Yamauchi, Keiju Sawada, Yuji Ohashi, Tadashi Eguchi, Katsumi Kakinuma

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

A highly enantioselective synthetic methodology for (R)-mevalonolactone has been developed based upon the chirality-transcription approach using a chiral template, diacetone-D-glucos-3-ulose 2. (R)-Mevalonolactone 1a is prepared from ketone 2 in 5 steps in 11% overall yield. This methodology is further applied to the synthesis of fully deuteriated (R)-[2H9]mevalonolactone 1b starting from ketone 2 and methyl [2H7]senecioate 7.

本文言語英語
ページ(範囲)891-895
ページ数5
ジャーナルJournal of the Chemical Society - Perkin Transactions 1
6
DOI
出版ステータス出版済み - 3 21 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

フィンガープリント 「Diacetone-glucose architecture as a chirality template. Part 9. Enantioselectiye synthesis of (R)-mevalonolactone and (R)-[<sup>2</sup>H<sub>9</sub>]mevalonolactone on carbohydrate template」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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