Diagnostic investigation using pancreatic juice

Takao Ohtsuka, Fumihiko Ookubo, Masao Tanaka

研究成果: 著書/レポートタイプへの貢献

抄録

Although endoscopic retrograde pancreatography to collect pancreatic juice sample for intraductal papillary mucinous neoplasms (IPMNs) of the pancreas is not routinely recommended because of its possible severe complication of pancreatitis, assessments of cytology and molecular markers in pancreatic juice are often useful to diagnose malignant IPMNs. In addition, pancreatic juice cytology is the only way to detect early stage pancreatic ductal adenocarcinoma concomitant with IPMNs which cannot be detected by imaging modalities such as computed tomography, magnetic resonance imaging, or endoscopic ultrasonography. The sensitivity of pancreatic juice cytology for malignant IPMNs is not high, ranging from 10 % to 50 %; however, several molecular markers in pancreatic juice such as carcinoembryonic antigen level, MUC1 level, and the activity of telomerase improve the sensitivity. Pancreatic juice cytology also provides the information regarding subtypes of IPMNs, namely, gastric, intestinal, pancreatobiliary, and oncocytic by the assessments of morphological features and immunohistochemistry. On the other hand, it remains unclear which patients with IPMN are indication for pancreatic juice assessment and which patients really get benefits of such investigation.

元の言語英語
ホスト出版物のタイトルIntraductal Papillary Mucinous Neoplasm of the Pancreas
出版者Springer Japan
ページ103-113
ページ数11
ISBN(電子版)9784431544722
ISBN(印刷物)4431544712, 9784431544715
DOI
出版物ステータス出版済み - 11 1 2013

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Pancreatic Juice
Cell Biology
Neoplasms
Endosonography
Telomerase
Carcinoembryonic Antigen
Pancreatic Neoplasms
Pancreatitis
Stomach Neoplasms
Adenocarcinoma
Immunohistochemistry
Tomography
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Ohtsuka, T., Ookubo, F., & Tanaka, M. (2013). Diagnostic investigation using pancreatic juice. : Intraductal Papillary Mucinous Neoplasm of the Pancreas (pp. 103-113). Springer Japan. https://doi.org/10.1007/978-4-431-54472-2_8

Diagnostic investigation using pancreatic juice. / Ohtsuka, Takao; Ookubo, Fumihiko; Tanaka, Masao.

Intraductal Papillary Mucinous Neoplasm of the Pancreas. Springer Japan, 2013. p. 103-113.

研究成果: 著書/レポートタイプへの貢献

Ohtsuka, T, Ookubo, F & Tanaka, M 2013, Diagnostic investigation using pancreatic juice. : Intraductal Papillary Mucinous Neoplasm of the Pancreas. Springer Japan, pp. 103-113. https://doi.org/10.1007/978-4-431-54472-2_8
Ohtsuka T, Ookubo F, Tanaka M. Diagnostic investigation using pancreatic juice. : Intraductal Papillary Mucinous Neoplasm of the Pancreas. Springer Japan. 2013. p. 103-113 https://doi.org/10.1007/978-4-431-54472-2_8
Ohtsuka, Takao ; Ookubo, Fumihiko ; Tanaka, Masao. / Diagnostic investigation using pancreatic juice. Intraductal Papillary Mucinous Neoplasm of the Pancreas. Springer Japan, 2013. pp. 103-113
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N2 - Although endoscopic retrograde pancreatography to collect pancreatic juice sample for intraductal papillary mucinous neoplasms (IPMNs) of the pancreas is not routinely recommended because of its possible severe complication of pancreatitis, assessments of cytology and molecular markers in pancreatic juice are often useful to diagnose malignant IPMNs. In addition, pancreatic juice cytology is the only way to detect early stage pancreatic ductal adenocarcinoma concomitant with IPMNs which cannot be detected by imaging modalities such as computed tomography, magnetic resonance imaging, or endoscopic ultrasonography. The sensitivity of pancreatic juice cytology for malignant IPMNs is not high, ranging from 10 % to 50 %; however, several molecular markers in pancreatic juice such as carcinoembryonic antigen level, MUC1 level, and the activity of telomerase improve the sensitivity. Pancreatic juice cytology also provides the information regarding subtypes of IPMNs, namely, gastric, intestinal, pancreatobiliary, and oncocytic by the assessments of morphological features and immunohistochemistry. On the other hand, it remains unclear which patients with IPMN are indication for pancreatic juice assessment and which patients really get benefits of such investigation.

AB - Although endoscopic retrograde pancreatography to collect pancreatic juice sample for intraductal papillary mucinous neoplasms (IPMNs) of the pancreas is not routinely recommended because of its possible severe complication of pancreatitis, assessments of cytology and molecular markers in pancreatic juice are often useful to diagnose malignant IPMNs. In addition, pancreatic juice cytology is the only way to detect early stage pancreatic ductal adenocarcinoma concomitant with IPMNs which cannot be detected by imaging modalities such as computed tomography, magnetic resonance imaging, or endoscopic ultrasonography. The sensitivity of pancreatic juice cytology for malignant IPMNs is not high, ranging from 10 % to 50 %; however, several molecular markers in pancreatic juice such as carcinoembryonic antigen level, MUC1 level, and the activity of telomerase improve the sensitivity. Pancreatic juice cytology also provides the information regarding subtypes of IPMNs, namely, gastric, intestinal, pancreatobiliary, and oncocytic by the assessments of morphological features and immunohistochemistry. On the other hand, it remains unclear which patients with IPMN are indication for pancreatic juice assessment and which patients really get benefits of such investigation.

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