Diagnostic performance of apparent diffusion coefficient for predicting histological grade of hepatocellular carcinoma

Akihiro Nishie, Tsuyoshi Tajima, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Tomohiro Nakayama, Yukihisa Takayama, Daisuke Okamoto, Nobuhiro Fujita, Akinobu Taketomi, Kengo Yoshimitsu, Hiroshi Honda

研究成果: ジャーナルへの寄稿学術誌査読

97 被引用数 (Scopus)

抄録

Objective: To investigate whether the histological grade of hepatocellular carcinoma (HCC) can be predicted using the apparent diffusion coefficient (ADC). Materials and Methods: This retrospective study group consisted of 80 patients with 85 surgically resected HCCs who underwent preoperative MRI exams including diffusion-weighted imaging. The tumors were histologically classified into five groups as follows: five well (w-), 17 well to moderately (wm-), 37 moderately (m-), 16 moderately to poorly (mp-), and 10 poorly (p-) differentiated HCCs. For ADC measurement of each HCC, the largest possible region of interest was placed on the solid region on the ADC map where ADC was considered to be the lowest. The average ADCs of the five histological grades were compared using Spearman's rank correlation test and Student's t-test, and the diagnostic performance of ADC for mp- and p-HCCs was also evaluated using a receiver operating characteristic-based positive test. Results: The average ADC of p-HCC (0.76 ± 0.10 × 10 -3 mm 2/s) was significantly lower than those of the other four histological grades. The average ADC of mp-HCCs (0.99 ± 0.20 × 10 -3 mm 2/s) was significantly lower than those of w-, wm- and m-HCCs. The sensitivity, specificity, PPV, NPV, and accuracy, when an ADC of 0.972 or lower was considered an indicator of mp- and p-HCCs, were 73.1%, 72.9%, 54.3%, 86.0% and 72.9%, respectively. Conclusion: ADCs of mp- and p-HCCs were lower than those of w-, wm- and m-HCCs. ADC can contribute to radiological diagnosis of poorly differentiated components in HCCs.

本文言語英語
ページ(範囲)e29-e33
ジャーナルEuropean Journal of Radiology
80
2
DOI
出版ステータス出版済み - 11月 2011

!!!All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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