Diagnostic value of FDG-PET/CT for the identification of extranodal extension in patients with head and neck squamous cell carcinoma

Ryo Toya, Tetsuo Saito, Tomohiko Matsuyama, Yudai Kai, Shinya Shiraishi, Daizo Murakami, Ryoji Yoshida, Takahiro Watakabe, Fumi Sakamoto, Noriko Tsuda, Hidetaka Arimura, Yorihisa Orita, Hideki Nakayama, Natsuo Oya

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

Background/Aim: We evaluated the diagnostic value of functional imaging with [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) for the identification of extranodal extension (ENE) in patients with head and neck squamous cell carcinoma (HNSCC). Patients and Methods: In this study, 94 patients with HNSCC who underwent FDG-PET/CT were enrolled. We recorded the maximum standardized uptake value (SUVmax), compared the results with pathologic findings, and evaluated the diagnostic performance of using a SUVmax cut-off value for ENE. Results: Of the 566 dissected levels examined, 53 (9.4%) exhibited ENE. The mean SUVmax of LN with and without ENE were 6.67 and 1.64, respectively (p<0.001). A receiver operating characteristics (ROC) curve analysis for SUVmax showed an area under the ROC curve of 0.913. A SUVmax cutoff of 3.0 achieved diagnostic performance for identifying ENE with sensitivity, specificity, and accuracy of 81.1%, 94.3% and 93.1%, respectively. Conclusion: FDG-PET/CT findings using a SUVmax cut-off of 3.0 provides appropriate diagnostic value in identifying ENE.

本文言語英語
ページ(範囲)2073-2077
ページ数5
ジャーナルAnticancer research
40
4
DOI
出版ステータス出版済み - 4 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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