Dialkyl bisphosphonate platinum(II) complex as a potential drug for metastatic bone tumor

Hidetoshi Nakatake, Hisao Ekimoto, Mariko Aso, Atsushi Ogawa, Asami Yamaguchi, Hiroshi Suemune

研究成果: ジャーナルへの寄稿記事

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Bisphosphonates have high affinity for hydroxyapatite (HA), which is abundantly present in bone. Also, platinum complexes are known that have a wide spectrum of antitumor activities. The conjugate of bisphosphonate and a platinum complex might have HA affinity and antitumor activity, and become a drug for metastatic bone tumor. In this study, the authors synthesized platinum complexes that had dialkyl bisphosphonic acid as a ligand, and evaluated the possibility of the synthesized complexes as a drug for metastatic bone tumor. The synthesized dialkyl bisphosphonate platinum(II) complex was characterized, and its stability in an aqueous solution was also confirmed. The synthesized platinum complex showed higher HA affinity than other platinum complexes such as cisplatin and carboplatin in an experiment of adsorption to HA. In vitro, the platinum complex showed tumor growth inhibitory effect stronger than or equal to cisplatin, which is the most commonly used antitumor agent. Moreover, the platinum complex showed a bone absorption inhibitory effect on the osteoclast. These results suggest potential of dialkyl bisphosphonate platinum(II) complexes as a drug for metastatic bone tumor.

元の言語英語
ページ(範囲)710-713
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
59
発行部数6
DOI
出版物ステータス出版済み - 6 6 2011

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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