Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-α-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression

Manabu Takano, Toshiyuki Arai, Yasuji Mokuno, Hitoshi Nishimura, Yuji Nimura, Yasunobu Yoshikai

研究成果: ジャーナルへの寄稿学術誌査読

26 被引用数 (Scopus)

抄録

Liver injury accompanied by apoptosis of hepatocytes was provoked in mice by an intravenous injection of recombinant tumor necrosis factor-α (rTNF-α) (1.0 μg/kg) together with an intraperitoneal injection of D-galactosamine (D-gal) (500 mg/kg). Injection of various doses of dibutyryl cAMP (DBcAMP) protected mice from TNF-α/D-gal-induced liver injury as assessed by serum alanine aminotransferase (ALT) levels, histological examination and DNA fragmentation. DBcAMP significantly enhanced the Hsp70 expression in the hepatocytes of D-gal/TNF-α-injected mice in close correlation with suppression of liver injury. DBcAMP induced Hsp70 expression in the hepatocyte in vitro. These results suggest that increase in Hsp70 expression by DBcAMP is involved in protective mechanisms by DBcAMP against TNF-α-induced liver injury in D-gal-sensitized mice.

本文言語英語
ページ(範囲)109-117
ページ数9
ジャーナルCell Stress and Chaperones
3
2
DOI
出版ステータス出版済み - 6月 1998
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 細胞生物学

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