Dietary conjugated linoleic acid increases immunoglobulin productivity of sprague-dawley rat spleen lymphocytes

Masao Yamasaki, Koji Kishihara, Keiko Mansho, Yuuya Ogino, Masaaki Kasai, Michihiro Sugano, Hirofumi Tachibana, Koji Yamada

研究成果: ジャーナルへの寄稿学術誌査読

57 被引用数 (Scopus)

抄録

The dietary effects of conjugated linoleic acid (CLA) on Ig production of Sprague-Dawley rats were examined at various doses such as 0 (control), 0.05, 0.10, 0.25, and 0.50%. CLA increased IgG and IgM production of spleen lymphocytes in a dose-dependent manner, and these levels reached a plateau at 0.25%. IgA production was not detected in the control group, while it was detected in all CLA-fed groups and IgA productivity of spleen lymphocytes increased in a dose-dependent manner at the doses from 0.05 to 0.50%. Dietary CLA did not affect serum Ig levels. The major fatty acid composition of spleen lymphocytes was not affected by dietary CLA, which itself was hardly incorporated into the cells. In an in vitro assay, the effects of CLA and its oxidative derivatives, furan type fatty acids, on Ig productivity were also examined. As a result, 100 μM CLA suppressed Ig production of spleen lymphocytes and the degree was as follows IgA>IgG>IgM. Each CLA isomer and the furan type fatty acids also suppressed Ig production but the degree was weaker than the mixture of CLA isomers. In this result, dietary CLA increased Ig productivity of spleen lymphocytes in vivo.

本文言語英語
ページ(範囲)2159-2164
ページ数6
ジャーナルBioscience, Biotechnology and Biochemistry
64
10
DOI
出版ステータス出版済み - 2000

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

フィンガープリント

「Dietary conjugated linoleic acid increases immunoglobulin productivity of sprague-dawley rat spleen lymphocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル