Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice

Shoichiro Tsuyama, Daichi Oikawa, Yukiko Tsuji, Yoriko Akimoto, Hiroyuki Jikuya, Mitsuhiro Furuse

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

Conjugated linoleic acid (CLA) has a role of biogenic regulation through modifying prostaglandin production. However, its effects on related metabolites of arachidonate remain unclear. Therefore, the effects of CLA on brain endocannabinoid content as well as its analogs were investigated.Mice (3-week-old), provided with diets containing 3% linoleic acid or 3% CLA for 4 weeks, were sacrificed and lipids were extracted from their cerebral cortex and hypothalamus. The amounts of N-arachidonoyl-ethanolamide, 2-arachidonoyl- glycerol (2-AG), oleoyl-ethanolamide and palmitoylethanolamide were determined quantitatively by LC-MS. The 2-AG level in the cerebral cortex was significantly decreased by CLA treatment, but the other compounds were unaffected in the cerebral cortex and hypothalamus. The present study indicated that dietary CLA site-selectively decreases 2-AG in the cerebral cortex.

本文言語英語
ページ(範囲)155-159
ページ数5
ジャーナルNutritional Neuroscience
12
4
DOI
出版ステータス出版済み - 8 1 2009

All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 神経科学(全般)
  • 栄養および糖尿病

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