Dietary D-allulose alters cholesterol metabolism in Golden Syrian hamsters partly by reducing serum PCSK9 levels

Akane Kanasaki, Zhe Jiang, Takuya Mizokami, Bungo Shirouchi, Tetsuo Iida, Yasuo Nagata, Masao Sato

研究成果: ジャーナルへの寄稿記事

抄録

D-Allulose, a C-3 epimer of D-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary D-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of D-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% D-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, D-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary D-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, D-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters.

元の言語英語
記事番号103429
ジャーナルJournal of Functional Foods
60
DOI
出版物ステータス出版済み - 9 1 2019

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psicose
cholesterol metabolism
subtilisin
Mesocricetus
Cholesterol
hamsters
Cricetinae
Serum
High Fat Diet
high fat diet
Diet
diet
Sweetening Agents
sweeteners
hyperglycemia
Mesocricetus auratus
Proprotein Convertase 9
Fructose
low density lipoprotein cholesterol
Lipid Metabolism

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

これを引用

Dietary D-allulose alters cholesterol metabolism in Golden Syrian hamsters partly by reducing serum PCSK9 levels. / Kanasaki, Akane; Jiang, Zhe; Mizokami, Takuya; Shirouchi, Bungo; Iida, Tetsuo; Nagata, Yasuo; Sato, Masao.

:: Journal of Functional Foods, 巻 60, 103429, 01.09.2019.

研究成果: ジャーナルへの寄稿記事

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abstract = "D-Allulose, a C-3 epimer of D-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary D-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of D-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3{\%} D-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, D-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary D-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, D-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters.",
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AU - Kanasaki, Akane

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AU - Shirouchi, Bungo

AU - Iida, Tetsuo

AU - Nagata, Yasuo

AU - Sato, Masao

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