TY - JOUR
T1 - Dietary D-allulose alters cholesterol metabolism in Golden Syrian hamsters partly by reducing serum PCSK9 levels
AU - Kanasaki, Akane
AU - Jiang, Zhe
AU - Mizokami, Takuya
AU - Shirouchi, Bungo
AU - Iida, Tetsuo
AU - Nagata, Yasuo
AU - Sato, Masao
N1 - Funding Information:
The study was funded by Matsutani Chemical Industry Co. Ltd. (Itami, Japan). A.K. and T.I. are employees and Y.N. is currently a part time consultant for this company.
Publisher Copyright:
© 2019 Elsevier Ltd
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/9
Y1 - 2019/9
N2 - D-Allulose, a C-3 epimer of D-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary D-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of D-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% D-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, D-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary D-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, D-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters.
AB - D-Allulose, a C-3 epimer of D-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary D-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of D-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% D-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, D-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary D-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, D-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters.
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U2 - 10.1016/j.jff.2019.103429
DO - 10.1016/j.jff.2019.103429
M3 - Article
AN - SCOPUS:85067952974
SN - 1756-4646
VL - 60
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 103429
ER -
