It has been reported that dietary Chlorella reinforces the immune system and protects rodents against bacteria and cancer. These effects are attributed to the increment of helper T cell type I population responsible for the cellular immunity. In this study we examined whether dietary Chlorella pyrenoidosa powder (CPP) influences the production of immunoglobulins (Ig) which play an important part in the humoral immunity. After CPP was fed to SD rats for 3 weeks, IgM concentration of the serum and IgM productivity of mesenteric lymph node (MLN) lymphocytes were dose-dependently increased. Dose-independent IgG productivity of spleen and MLN lymphocytes was also enhanced. These results showed that dietary CPP reinforced IgM immunoglobulin production and may be useful for activation of host defenses.
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