Dietary effect of tocopherols and tocotrienols on the immune function of spleen and mesenteric lymph node lymphocytes in brown norway rats

Jiongyan Gu, Yoko Wakizono, Yousuke Sunada, Phum Hung, Michiko Nonaka, Michihiro Sugano, Koji Yamada

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

抄録

The immunoregulatory effects of dietary α-tocopherol (Toc) and tocotrienols (T-3) on humoral and cell-mediated immunity and cytokine productions were examined in Brown Norway rats. We found that the IgA and IgG productivity of spleen and mesenteric lymph node (MLN) lymphocytes was significantly enhanced in the rats fed on Toc or T-3, irrespective of concanavalin A (Con A) stimulation of the lymphocytes. On the contrary, the IgE productivity of lymphocytes from the rats fed on Toc or T-3 was less without Con A stimulation, but was greater in the presence of Con A, especially in the T-3 group. Toc or T-3 feeding significantly decreased the proportion of CD4+ T cells and the ratio of CD4+/CD8+ in both spleen and MLN lymphocytes of the rats fed on Toc or T-3. The interferon-γ productivity of MLN lymphocytes was higher in the rats fed on Toc or T-3 than in those fed on a control diet in the presence of Con A, while that of spleen lymphocytes was lower in the rats fed on Toc or T-3. In addition, T-3 feeding decreased the productivity of tumor necrosis factor-α of spleen lymphocytes, while it enhanced the productivity of MLN lymphocytes. These results suggest that oral administration of Toc and T-3 affects the proliferation and function of spleen and MLN lymphocytes.

元の言語英語
ページ(範囲)1697-1702
ページ数6
ジャーナルBioscience, Biotechnology and Biochemistry
63
発行部数10
DOI
出版物ステータス出版済み - 1 1 1999

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Tocotrienols
Tocopherols
Lymphocytes
Rats
Spleen
Lymph Nodes
Concanavalin A
Productivity
CD4-CD8 Ratio
T-cells
Lymphocyte Activation
Cellular Immunity
Immunoglobulin A
Interferons
Immunoglobulin E
Nutrition
Oral Administration
Tumor Necrosis Factor-alpha
Immunoglobulin G
Cytokines

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

これを引用

Dietary effect of tocopherols and tocotrienols on the immune function of spleen and mesenteric lymph node lymphocytes in brown norway rats. / Gu, Jiongyan; Wakizono, Yoko; Sunada, Yousuke; Hung, Phum; Nonaka, Michiko; Sugano, Michihiro; Yamada, Koji.

:: Bioscience, Biotechnology and Biochemistry, 巻 63, 番号 10, 01.01.1999, p. 1697-1702.

研究成果: ジャーナルへの寄稿記事

Gu, Jiongyan ; Wakizono, Yoko ; Sunada, Yousuke ; Hung, Phum ; Nonaka, Michiko ; Sugano, Michihiro ; Yamada, Koji. / Dietary effect of tocopherols and tocotrienols on the immune function of spleen and mesenteric lymph node lymphocytes in brown norway rats. :: Bioscience, Biotechnology and Biochemistry. 1999 ; 巻 63, 番号 10. pp. 1697-1702.
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