Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in sprague-dawley rats

Pham Hung, Jiongyan Gu, Shihoko Kaku, Shin Ichi Yunoki, Ken Ichi Ohkura, Ikuo Ikeda, Hirofumi Tachibana, Michihiro Sugano, Kazunaga Yazawa, Koji Yamada

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

抄録

Sprague-Dawley rats were fed eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) ethyl esters at the 2% level for 3 weeks to clarify their effects on immune functions. In the rats fed EPA or DHA, serum cholesterol, triglyceride, and phospholipid (PL) levels were significantly lower than those in the rats fed safflower oil. In PL fractions of serum, liver, lung, splenocytes, and peritoneal exudate cells (PEC), increases in linoleic and dihomo-γ-linolenic acid contents and a decrease in arachidonic acid (AA) content were observed in the rats fed EPA or DHA. In addition, the EPA content increased in the rats fed EPA and DHA. In the rats fed EPA or DHA, a decrease of LTB4 productivity and an increase of LTB5 productivity were observed in the PEC, in response to the treatment with 5 μM calcium ionophore A23187 for 20 min. The changes in leukotriene production were more marked in EPA-fed rats than in DHA-fed rats. These results suggest that dietary EPA affects lipid metabolism and leukotriene synthesis more strongly than DHA.

元の言語英語
ページ(範囲)2588-2593
ページ数6
ジャーナルBioscience, Biotechnology and Biochemistry
64
発行部数12
DOI
出版物ステータス出版済み - 1 1 2000

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Eicosapentaenoic Acid
Docosahexaenoic Acids
Lipid Metabolism
Sprague Dawley Rats
Rats
Esters
Leukotrienes
Exudates and Transudates
Phospholipids
Safflower Oil
Productivity
Leukotriene B4
alpha-Linolenic Acid
Calcium Ionophores
Calcimycin
Serum
Arachidonic Acid
Liver
Triglycerides
Cholesterol

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

これを引用

Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in sprague-dawley rats. / Hung, Pham; Gu, Jiongyan; Kaku, Shihoko; Yunoki, Shin Ichi; Ohkura, Ken Ichi; Ikeda, Ikuo; Tachibana, Hirofumi; Sugano, Michihiro; Yazawa, Kazunaga; Yamada, Koji.

:: Bioscience, Biotechnology and Biochemistry, 巻 64, 番号 12, 01.01.2000, p. 2588-2593.

研究成果: ジャーナルへの寄稿記事

Hung, Pham ; Gu, Jiongyan ; Kaku, Shihoko ; Yunoki, Shin Ichi ; Ohkura, Ken Ichi ; Ikeda, Ikuo ; Tachibana, Hirofumi ; Sugano, Michihiro ; Yazawa, Kazunaga ; Yamada, Koji. / Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in sprague-dawley rats. :: Bioscience, Biotechnology and Biochemistry. 2000 ; 巻 64, 番号 12. pp. 2588-2593.
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abstract = "Sprague-Dawley rats were fed eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) ethyl esters at the 2{\%} level for 3 weeks to clarify their effects on immune functions. In the rats fed EPA or DHA, serum cholesterol, triglyceride, and phospholipid (PL) levels were significantly lower than those in the rats fed safflower oil. In PL fractions of serum, liver, lung, splenocytes, and peritoneal exudate cells (PEC), increases in linoleic and dihomo-γ-linolenic acid contents and a decrease in arachidonic acid (AA) content were observed in the rats fed EPA or DHA. In addition, the EPA content increased in the rats fed EPA and DHA. In the rats fed EPA or DHA, a decrease of LTB4 productivity and an increase of LTB5 productivity were observed in the PEC, in response to the treatment with 5 μM calcium ionophore A23187 for 20 min. The changes in leukotriene production were more marked in EPA-fed rats than in DHA-fed rats. These results suggest that dietary EPA affects lipid metabolism and leukotriene synthesis more strongly than DHA.",
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AU - Ikeda, Ikuo

AU - Tachibana, Hirofumi

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