Dietary intake of metals and risk of Parkinson's disease: A case-control study in Japan

Yoshihiro Miyake, Keiko Tanaka, Wakaba Fukushima, Satoshi Sasaki, Chikako Kiyohara, Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oeda, Takami Miki, Nobutoshi Kawamura, Nobutaka Sakae, Hidenao Fukuyama, Yoshio Hirota, Masaki Nagai, Yasuhiko Baba, Tomonori Kobayashi, Hideyuki Sawada, Eiji Mizuta, Nagako Murase, Tsuyoshi TsutadaHiroyuki Shimada, Jun-Ichi Kira, Tameko Kihira, Tomoyoshi Kondo, Hidekazu Tomimoto, Takayuki Taniwaki, Hiroshi Sugiyama, Sonoyo Yoshida, Harutoshi Fujimura, Tomoko Saito, Kyoko Saida, Junko Fujitake, Naoki Fujii, Masatoshi Naito, Jun Arimizu, Takashi Nakagawa, Hirofumi Harada, Takayuki Sueta, Toshihiro Kikuta, George Umemoto, Eiichi Uchio, Hironori Migita, Kenichi Kazuki, Yoichi Ito, Hiroyoshi Iwaki, Kunihiko Siraki, Shinsuke Ataka, Hideo Yamane, Rie Tochino, Teruichi Harada, Yasushi Iwashita, Motoyuki Shimizu, Kenji Seki, Keiji Ando

研究成果: Contribution to journalArticle査読

49 被引用数 (Scopus)

抄録

Metals are involved in several important functions in the nervous system. Zinc and iron are increased and copper is decreased in the substantia nigra in Parkinson's disease (PD). However, epidemiological evidence for the association of dietary intake of metals with the risk of PD is limited. We investigated the relationship between metal consumption and the risk of PD in Japan using data from a multicenter hospital-based case-control study. Included were 249 cases within 6 years of onset of PD based on the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a self-administered diet history questionnaire. Higher intake of iron, magnesium, and zinc was independently associated with a reduced risk of PD: the adjusted OR in the highest quartile was 0.24 (95% CI: 0.10-0.57, P for trend = 0.0003) for iron, 0.33 (95% CI: 0.13-0.81, P for trend = 0.007) for magnesium and 0.50 (95% CI: 0.26-0.95, P for trend = 0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD.

本文言語英語
ページ(範囲)98-102
ページ数5
ジャーナルJournal of the Neurological Sciences
306
1-2
DOI
出版ステータス出版済み - 7 15 2011

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学

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