Dietary patterns and the risk of systemic lupus erythematosus in a Japanese population: The Kyushu Sapporo SLE (KYSS) Study

the Kyushu Sapporo SLE (KYSS) Study Group

研究成果: ジャーナルへの寄稿記事

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Background: Dietary factors are major regulators of immune function. As systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder, dietary factors are probably associated with SLE risk. However, there are very limited studies on the association between SLE risk and diet. Methods: Factor analysis of 30 food items was performed to identify dietary patterns in 125 female SLE patients and 344 female controls. Dietary information was obtained by a self-administered food frequency questionnaire. Unconditional logistic regression was used to compute the odds ratios (ORs) and their 95% confidence intervals (CIs), with adjustments for several covariates. Results: We identified three dietary patterns: vegetable, meat and dairy product patterns. After adjustment for potential confounders, the dairy product pattern was significantly associated with an increased risk of SLE. Adjusted ORs (95% CI) for SLE in the first, second, third and fourth quartiles of the dairy product pattern were 1.00 (reference), 1.76 (0.89 - 3.54), 2.25 (1.15 - 4.43) and 1.97 (0.98 - 3.95), respectively (Ptrend = 0.045). The other two dietary patterns were not associated with SLE risk. Conclusion: The dairy product pattern may be associated with an increased risk of SLE. Additional studies are warranted to confirm the findings suggested in this study.

元の言語英語
ページ(範囲)110-115
ページ数6
ジャーナルInternational Medical Journal
22
発行部数3
出版物ステータス出版済み - 1 1 2015

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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