Dietary Sparassis crispa reduces body fat mass and hepatic lipid levels by enhancing energy expenditure and suppressing lipogenesis in rats

Ai Takeyama, Yasuo Nagata, Bungo Shirouchi, Chika Nonaka, Hiromu Aoki, Tsubasa Haraguchi, Masao Sato, Kei Tamaya, Hideto Yamamoto, Kazunari Tanaka

研究成果: ジャーナルへの寄稿記事

抄録

Accumulation of abdominal fat triggers metabolic syndrome, which is a cluster of metabolic abnormalities, such as dyslipidemia, glucose intolerance, insulin resistance or hyperinsulinemia, and hypertension, that leads to the development of diabetes and cardiovascular disease. Mushrooms have been used as a foodstuff and folk medicine worldwide. Among these mushrooms, Sparassis crispa (SC) is a relatively newly cultivated edible and medicinal mushroom, which has been reported to have anti-diabetic and anti-hypertensive properties. However, little is known about the anti-obesity and anti-hyperlipidemic properties of SC. In the present study, we investigated the effects of dietary SC on lipid metabolism and energy expenditure in Sprague-Dawley rats with diet-induced obesity and diabetes, and conducted respiratory gas analysis to determine how energy metabolism is altered by SC. After feeding periods of 3 and 7 weeks, dietary SC had significantly reduced hepatic triacylglycerol and cholesterol contents in a dose-dependent manner. These changes were attributable to suppression of fatty acid and cholesterol synthesis in the liver and increased insulin sensitivity in the body. In addition, after a feeding period of 6 weeks, dietary SC significantly increased energy expenditure through carbohydrate oxidation, reducing abdominal fat mass after 7 weeks. In conclusion, our results indicate that in addition to the previously reported anti-diabetic and anti-hypertensive activities, dietary SC exhibits anti-obesity and anti-hyperlipidemic activities that help protect against metabolic syndrome.

元の言語英語
ページ(範囲)1137-1147
ページ数11
ジャーナルJournal of oleo science
67
発行部数9
DOI
出版物ステータス出版済み - 1 1 2018

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Oils and fats
Lipids
Rats
Insulin
Cholesterol
Fats
Medical problems
Antihypertensive Agents
Gas fuel analysis
Carbohydrates
Nutrition
Fatty acids
Liver
Medicine
Glucose
Triglycerides
Fatty Acids
Oxidation
Energy Metabolism
Lipogenesis

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

これを引用

Dietary Sparassis crispa reduces body fat mass and hepatic lipid levels by enhancing energy expenditure and suppressing lipogenesis in rats. / Takeyama, Ai; Nagata, Yasuo; Shirouchi, Bungo; Nonaka, Chika; Aoki, Hiromu; Haraguchi, Tsubasa; Sato, Masao; Tamaya, Kei; Yamamoto, Hideto; Tanaka, Kazunari.

:: Journal of oleo science, 巻 67, 番号 9, 01.01.2018, p. 1137-1147.

研究成果: ジャーナルへの寄稿記事

Takeyama, Ai ; Nagata, Yasuo ; Shirouchi, Bungo ; Nonaka, Chika ; Aoki, Hiromu ; Haraguchi, Tsubasa ; Sato, Masao ; Tamaya, Kei ; Yamamoto, Hideto ; Tanaka, Kazunari. / Dietary Sparassis crispa reduces body fat mass and hepatic lipid levels by enhancing energy expenditure and suppressing lipogenesis in rats. :: Journal of oleo science. 2018 ; 巻 67, 番号 9. pp. 1137-1147.
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abstract = "Accumulation of abdominal fat triggers metabolic syndrome, which is a cluster of metabolic abnormalities, such as dyslipidemia, glucose intolerance, insulin resistance or hyperinsulinemia, and hypertension, that leads to the development of diabetes and cardiovascular disease. Mushrooms have been used as a foodstuff and folk medicine worldwide. Among these mushrooms, Sparassis crispa (SC) is a relatively newly cultivated edible and medicinal mushroom, which has been reported to have anti-diabetic and anti-hypertensive properties. However, little is known about the anti-obesity and anti-hyperlipidemic properties of SC. In the present study, we investigated the effects of dietary SC on lipid metabolism and energy expenditure in Sprague-Dawley rats with diet-induced obesity and diabetes, and conducted respiratory gas analysis to determine how energy metabolism is altered by SC. After feeding periods of 3 and 7 weeks, dietary SC had significantly reduced hepatic triacylglycerol and cholesterol contents in a dose-dependent manner. These changes were attributable to suppression of fatty acid and cholesterol synthesis in the liver and increased insulin sensitivity in the body. In addition, after a feeding period of 6 weeks, dietary SC significantly increased energy expenditure through carbohydrate oxidation, reducing abdominal fat mass after 7 weeks. In conclusion, our results indicate that in addition to the previously reported anti-diabetic and anti-hypertensive activities, dietary SC exhibits anti-obesity and anti-hyperlipidemic activities that help protect against metabolic syndrome.",
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AU - Takeyama, Ai

AU - Nagata, Yasuo

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AU - Aoki, Hiromu

AU - Haraguchi, Tsubasa

AU - Sato, Masao

AU - Tamaya, Kei

AU - Yamamoto, Hideto

AU - Tanaka, Kazunari

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