Dietary supplementation with okara and Bacillus coagulans lilac-01 improves hepatic lipid accumulation induced by cholic acids in rats

Yeonmi Lee, Yasutake Tanaka, Wakana Iwasaki, Fumika Yokoyama, Ga Hyun Joe, Misaki Tsuji, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Hidehisa Shimizu, Kimiko Minamida, Kazunori Miwa, Satoshi Ishizuka

研究成果: ジャーナルへの寄稿学術誌査読

抄録

A dietary symbiotic supplement of okara, a by-product of tofu manufacturing with Bacillus coagulans lilac-01 found to reduce secondary bile acid (BA) in a rat study and cholic acid (CA), a primary 12α-hydroxylated (12αOH) BA, induces lipid accumulation in rats. In this study, we investigated whether dietary supplementation of a synbiotic with okara and Bacillus coagulans lilac-01 improves CA-induced hepatic lipid accumulation. Male Wistar/ST rats (4 weeks old) were fed with or without CA-supplementation combined with the synbiotic for 2 weeks. The CA diet increased hepatic triglycerides and the synbiotic diet in combination with CA normalized liver triglyceride concentration accompanied by suppression of hepatic fatty acid synthase expression, enhancement of fecal triglyceride excretion, and increase in fecal non-12αOH BA excretion. Dietary supplementation with the okara synbiotic ameliorated hepatic lipid accumulation probably by reducing de novo lipogenesis and enhancing fecal triglyceride excretion.

本文言語英語
論文番号104991
ジャーナルJournal of Functional Foods
90
DOI
出版ステータス出版済み - 3月 2022

!!!All Science Journal Classification (ASJC) codes

  • 食品科学
  • 医学(その他)
  • 栄養および糖尿病

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