Difference between substance P- and acetylcholine-induced currents in mammalian smooth muscle cells

Ken Nakazawa, Kazuhide Inoue, Kannosuke Fujimori, Akira Takanaka

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

The effects of substance P (SP) and acetylcholine (ACh) on membrane currents were compared using freshly isolated smooth muscle cells from guinea-pig ileum. Both SP (100 nM) and ACh (10μM) induced inward currents at negative holding potentials. The ACh-induced current, but not the SP-induced current, showed relaxation upon voltage-stepping. The SP-induced current was increased by hyperpolarization more negative than -50 mV whereas the ACh-induced current was decreased by hyperpolarization. The results suggest that the SP-induced inward current is elicited via an ionic pathway different from that involved with ACh-activated channels.

本文言語英語
ページ(範囲)453-456
ページ数4
ジャーナルEuropean Journal of Pharmacology
179
3
DOI
出版ステータス出版済み - 4 25 1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学

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