TY - JOUR
T1 - Difference between substance P- and acetylcholine-induced currents in mammalian smooth muscle cells
AU - Nakazawa, Ken
AU - Inoue, Kazuhide
AU - Fujimori, Kannosuke
AU - Takanaka, Akira
PY - 1990/4/25
Y1 - 1990/4/25
N2 - The effects of substance P (SP) and acetylcholine (ACh) on membrane currents were compared using freshly isolated smooth muscle cells from guinea-pig ileum. Both SP (100 nM) and ACh (10μM) induced inward currents at negative holding potentials. The ACh-induced current, but not the SP-induced current, showed relaxation upon voltage-stepping. The SP-induced current was increased by hyperpolarization more negative than -50 mV whereas the ACh-induced current was decreased by hyperpolarization. The results suggest that the SP-induced inward current is elicited via an ionic pathway different from that involved with ACh-activated channels.
AB - The effects of substance P (SP) and acetylcholine (ACh) on membrane currents were compared using freshly isolated smooth muscle cells from guinea-pig ileum. Both SP (100 nM) and ACh (10μM) induced inward currents at negative holding potentials. The ACh-induced current, but not the SP-induced current, showed relaxation upon voltage-stepping. The SP-induced current was increased by hyperpolarization more negative than -50 mV whereas the ACh-induced current was decreased by hyperpolarization. The results suggest that the SP-induced inward current is elicited via an ionic pathway different from that involved with ACh-activated channels.
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U2 - 10.1016/0014-2999(90)90188-C
DO - 10.1016/0014-2999(90)90188-C
M3 - Article
C2 - 1694769
AN - SCOPUS:0025217310
SN - 0014-2999
VL - 179
SP - 453
EP - 456
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -