Differences in the prognosis of resected lung adenocarcinoma according to the histological subtype: A retrospective analysis of Japanese lung cancer registry data

Hiroyuki Sakurai, Hisao Asamura, Etsuo Miyaoka, Ichiro Yoshino, Yoshitaka Fujii, Yoichi Nakanishi, Kenji Eguchi, Masaki Mori, Noriyoshi Sawabata, Meinoshin Okumura, Kohei Yokoi

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抄録

OBJECTIVES: This study intended to assess the clinicopathological features of the histological subtypes of adenocarcinoma of the lung in a large registry population. METHODS: The Japanese Joint Committee of Lung Cancer Registry performed a nationwide retrospective registry study on the prognosis and clinicopathological profiles of 11 663 patients who underwent resection for primary lung neoplasm in 2004. The registry data of 7921 (62.5%) patients with adenocarcinoma were analysed regarding the prognosis and clinicopathological features according to the histological subtype of adenocarcinoma. The histological subtypes were defined according to the 1999 World Health Organization classification (third edition), where bronchioloalveolar carcinoma (BAC) is defined as adenocarcinoma with a pure bronchioloalveolar growth pattern without invasion. RESULTS: The distribution of the histological subtype was acinar in 471 patients (7.5%), papillary in 2004 (32.2%), BAC in 1385 (22.3%), solid adenocarcinoma with mucin in 103 (1.7%) and adenocarcinoma with mixed subtypes (AMS) in 2257 (36.3%). The 5-year overall survival rates according to histological subtype were 63.4% for acinar, 72.9% for papillary, 90.3% for BAC, 54.4% for solid adenocarcinoma with mucin and 73.7% for AMS. While the survival rate in patients with BAC was significantly better than those for the other histological subtypes, acinar and solid adenocarcinoma with mucin had significantly worse prognoses than the other histological subtypes. The histological subtype was an independent predictor of survival in a multivariate analysis (P < 0.001). Regarding BAC, the pathological stage included not only Stage IA/IB (n = 1275; 92.1%), but also Stage II-IV (n = 110; 7.9%). One hundred twenty-five patients (9.0%) with BAC had recurrence, including both local and distant recurrence. CONCLUSIONS: The histological subtype in adenocarcinoma significantly correlated with the prognosis. In BACs with recurrence or pathological stage II-IV, these tumours might have been classified as invasive adenocarcinoma rather than as BAC. The need for the rigorous pathological evaluation of adenocarcinomas that are considered to be a preinvasive or minimally invasive tumour should be addressed in the new lung adenocarcinoma classification to be proposed by the International Association for the Study of Lung Cancer, the American Thoracic Society and the European Respiratory Society.

元の言語英語
記事番号ezt284
ページ(範囲)100-107
ページ数8
ジャーナルEuropean Journal of Cardio-thoracic Surgery
45
発行部数1
DOI
出版物ステータス出版済み - 1 1 2014

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Registries
Bronchiolo-Alveolar Adenocarcinoma
Lung Neoplasms
Adenocarcinoma
Mucins
Recurrence
Adenocarcinoma of lung
Survival Rate
Neoplasms
Multivariate Analysis
Retrospective Studies
Survival
Growth

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

これを引用

Differences in the prognosis of resected lung adenocarcinoma according to the histological subtype : A retrospective analysis of Japanese lung cancer registry data. / Sakurai, Hiroyuki; Asamura, Hisao; Miyaoka, Etsuo; Yoshino, Ichiro; Fujii, Yoshitaka; Nakanishi, Yoichi; Eguchi, Kenji; Mori, Masaki; Sawabata, Noriyoshi; Okumura, Meinoshin; Yokoi, Kohei.

:: European Journal of Cardio-thoracic Surgery, 巻 45, 番号 1, ezt284, 01.01.2014, p. 100-107.

研究成果: ジャーナルへの寄稿記事

Sakurai, H, Asamura, H, Miyaoka, E, Yoshino, I, Fujii, Y, Nakanishi, Y, Eguchi, K, Mori, M, Sawabata, N, Okumura, M & Yokoi, K 2014, 'Differences in the prognosis of resected lung adenocarcinoma according to the histological subtype: A retrospective analysis of Japanese lung cancer registry data', European Journal of Cardio-thoracic Surgery, 巻. 45, 番号 1, ezt284, pp. 100-107. https://doi.org/10.1093/ejcts/ezt284
Sakurai, Hiroyuki ; Asamura, Hisao ; Miyaoka, Etsuo ; Yoshino, Ichiro ; Fujii, Yoshitaka ; Nakanishi, Yoichi ; Eguchi, Kenji ; Mori, Masaki ; Sawabata, Noriyoshi ; Okumura, Meinoshin ; Yokoi, Kohei. / Differences in the prognosis of resected lung adenocarcinoma according to the histological subtype : A retrospective analysis of Japanese lung cancer registry data. :: European Journal of Cardio-thoracic Surgery. 2014 ; 巻 45, 番号 1. pp. 100-107.
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title = "Differences in the prognosis of resected lung adenocarcinoma according to the histological subtype: A retrospective analysis of Japanese lung cancer registry data",
abstract = "OBJECTIVES: This study intended to assess the clinicopathological features of the histological subtypes of adenocarcinoma of the lung in a large registry population. METHODS: The Japanese Joint Committee of Lung Cancer Registry performed a nationwide retrospective registry study on the prognosis and clinicopathological profiles of 11 663 patients who underwent resection for primary lung neoplasm in 2004. The registry data of 7921 (62.5{\%}) patients with adenocarcinoma were analysed regarding the prognosis and clinicopathological features according to the histological subtype of adenocarcinoma. The histological subtypes were defined according to the 1999 World Health Organization classification (third edition), where bronchioloalveolar carcinoma (BAC) is defined as adenocarcinoma with a pure bronchioloalveolar growth pattern without invasion. RESULTS: The distribution of the histological subtype was acinar in 471 patients (7.5{\%}), papillary in 2004 (32.2{\%}), BAC in 1385 (22.3{\%}), solid adenocarcinoma with mucin in 103 (1.7{\%}) and adenocarcinoma with mixed subtypes (AMS) in 2257 (36.3{\%}). The 5-year overall survival rates according to histological subtype were 63.4{\%} for acinar, 72.9{\%} for papillary, 90.3{\%} for BAC, 54.4{\%} for solid adenocarcinoma with mucin and 73.7{\%} for AMS. While the survival rate in patients with BAC was significantly better than those for the other histological subtypes, acinar and solid adenocarcinoma with mucin had significantly worse prognoses than the other histological subtypes. The histological subtype was an independent predictor of survival in a multivariate analysis (P < 0.001). Regarding BAC, the pathological stage included not only Stage IA/IB (n = 1275; 92.1{\%}), but also Stage II-IV (n = 110; 7.9{\%}). One hundred twenty-five patients (9.0{\%}) with BAC had recurrence, including both local and distant recurrence. CONCLUSIONS: The histological subtype in adenocarcinoma significantly correlated with the prognosis. In BACs with recurrence or pathological stage II-IV, these tumours might have been classified as invasive adenocarcinoma rather than as BAC. The need for the rigorous pathological evaluation of adenocarcinomas that are considered to be a preinvasive or minimally invasive tumour should be addressed in the new lung adenocarcinoma classification to be proposed by the International Association for the Study of Lung Cancer, the American Thoracic Society and the European Respiratory Society.",
author = "Hiroyuki Sakurai and Hisao Asamura and Etsuo Miyaoka and Ichiro Yoshino and Yoshitaka Fujii and Yoichi Nakanishi and Kenji Eguchi and Masaki Mori and Noriyoshi Sawabata and Meinoshin Okumura and Kohei Yokoi",
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T1 - Differences in the prognosis of resected lung adenocarcinoma according to the histological subtype

T2 - A retrospective analysis of Japanese lung cancer registry data

AU - Sakurai, Hiroyuki

AU - Asamura, Hisao

AU - Miyaoka, Etsuo

AU - Yoshino, Ichiro

AU - Fujii, Yoshitaka

AU - Nakanishi, Yoichi

AU - Eguchi, Kenji

AU - Mori, Masaki

AU - Sawabata, Noriyoshi

AU - Okumura, Meinoshin

AU - Yokoi, Kohei

PY - 2014/1/1

Y1 - 2014/1/1

N2 - OBJECTIVES: This study intended to assess the clinicopathological features of the histological subtypes of adenocarcinoma of the lung in a large registry population. METHODS: The Japanese Joint Committee of Lung Cancer Registry performed a nationwide retrospective registry study on the prognosis and clinicopathological profiles of 11 663 patients who underwent resection for primary lung neoplasm in 2004. The registry data of 7921 (62.5%) patients with adenocarcinoma were analysed regarding the prognosis and clinicopathological features according to the histological subtype of adenocarcinoma. The histological subtypes were defined according to the 1999 World Health Organization classification (third edition), where bronchioloalveolar carcinoma (BAC) is defined as adenocarcinoma with a pure bronchioloalveolar growth pattern without invasion. RESULTS: The distribution of the histological subtype was acinar in 471 patients (7.5%), papillary in 2004 (32.2%), BAC in 1385 (22.3%), solid adenocarcinoma with mucin in 103 (1.7%) and adenocarcinoma with mixed subtypes (AMS) in 2257 (36.3%). The 5-year overall survival rates according to histological subtype were 63.4% for acinar, 72.9% for papillary, 90.3% for BAC, 54.4% for solid adenocarcinoma with mucin and 73.7% for AMS. While the survival rate in patients with BAC was significantly better than those for the other histological subtypes, acinar and solid adenocarcinoma with mucin had significantly worse prognoses than the other histological subtypes. The histological subtype was an independent predictor of survival in a multivariate analysis (P < 0.001). Regarding BAC, the pathological stage included not only Stage IA/IB (n = 1275; 92.1%), but also Stage II-IV (n = 110; 7.9%). One hundred twenty-five patients (9.0%) with BAC had recurrence, including both local and distant recurrence. CONCLUSIONS: The histological subtype in adenocarcinoma significantly correlated with the prognosis. In BACs with recurrence or pathological stage II-IV, these tumours might have been classified as invasive adenocarcinoma rather than as BAC. The need for the rigorous pathological evaluation of adenocarcinomas that are considered to be a preinvasive or minimally invasive tumour should be addressed in the new lung adenocarcinoma classification to be proposed by the International Association for the Study of Lung Cancer, the American Thoracic Society and the European Respiratory Society.

AB - OBJECTIVES: This study intended to assess the clinicopathological features of the histological subtypes of adenocarcinoma of the lung in a large registry population. METHODS: The Japanese Joint Committee of Lung Cancer Registry performed a nationwide retrospective registry study on the prognosis and clinicopathological profiles of 11 663 patients who underwent resection for primary lung neoplasm in 2004. The registry data of 7921 (62.5%) patients with adenocarcinoma were analysed regarding the prognosis and clinicopathological features according to the histological subtype of adenocarcinoma. The histological subtypes were defined according to the 1999 World Health Organization classification (third edition), where bronchioloalveolar carcinoma (BAC) is defined as adenocarcinoma with a pure bronchioloalveolar growth pattern without invasion. RESULTS: The distribution of the histological subtype was acinar in 471 patients (7.5%), papillary in 2004 (32.2%), BAC in 1385 (22.3%), solid adenocarcinoma with mucin in 103 (1.7%) and adenocarcinoma with mixed subtypes (AMS) in 2257 (36.3%). The 5-year overall survival rates according to histological subtype were 63.4% for acinar, 72.9% for papillary, 90.3% for BAC, 54.4% for solid adenocarcinoma with mucin and 73.7% for AMS. While the survival rate in patients with BAC was significantly better than those for the other histological subtypes, acinar and solid adenocarcinoma with mucin had significantly worse prognoses than the other histological subtypes. The histological subtype was an independent predictor of survival in a multivariate analysis (P < 0.001). Regarding BAC, the pathological stage included not only Stage IA/IB (n = 1275; 92.1%), but also Stage II-IV (n = 110; 7.9%). One hundred twenty-five patients (9.0%) with BAC had recurrence, including both local and distant recurrence. CONCLUSIONS: The histological subtype in adenocarcinoma significantly correlated with the prognosis. In BACs with recurrence or pathological stage II-IV, these tumours might have been classified as invasive adenocarcinoma rather than as BAC. The need for the rigorous pathological evaluation of adenocarcinomas that are considered to be a preinvasive or minimally invasive tumour should be addressed in the new lung adenocarcinoma classification to be proposed by the International Association for the Study of Lung Cancer, the American Thoracic Society and the European Respiratory Society.

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