Differences in thymus-dependency among various T-cell functions

Y. Shimamoto, K. Taniguchi, C. Kubo, K. Nomoto

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Effects of thymectomy at various times after birth on cytotoxicity, delayed footpad reaction and antibody production were examined in 6 week old mice immunized intraperitoneally with chicken erythrocytes. Cytotoxicity and antibody production were abolished by thymectomy within 3 days after birth. Mice thymectomized at 5 days of age or later showed appreciable degrees of cytotoxicity and antibody production. On the other hand, a delayed footpad reaction could be elicited even in mice thymectomized within 24 h after birth, although the degree of the reaction was reduced by such a treatment. Therefore, T cells responsible for delayed hypersensitivity were less thymus-dependent and required the presence of the thymus for a shorter period in their development that those responsible for cytotoxicity or antibody production.

本文言語英語
ページ(範囲)167-178
ページ数12
ジャーナルImmunology
41
1
出版ステータス出版済み - 1980
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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