Different incretin responses after pancreatoduodenectomy and distal pancreatectomy

Yasuhisa Mori, Ohtsuka Takao, Kosuke Tsutsumi, Takaharu Yasui, Junji Ueda, Shunichi Takahata, Masafumi Nakamura, Masao Tanaka

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

OBJECTIVES: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are known as incretins to stimulate insulin secretion. The aims of this study were to investigate the postoperative β-cell function and hormonal responses of GLP-1 and GIP after pancreatoduodenectomy (PD) and distal pancreatectomy (DP). METHODS: Oral glucose tolerance tests were performed in 34 patients (20 PD and 14 DP) before and 1 month after operation. The changes in the serum glucose and insulin concentrations, homeostasis model assessment of insulin resistance, and pancreatic β-cell function (BCF) were analyzed. GLP-1 and GIP were also measured. RESULTS: There was no patient with postoperative deterioration of glucose tolerance after PD, whereas impairment of glucose metabolism was observed after DP. Homeostasis model assessment of insulin resistance decreased after PD, whereas those after DP showed no change. The postoperative BCF were lower than preoperative values in both groups. GLP-1 increased after DP but not after PD, whereas GIP decreased after PD but not after DP. CONCLUSIONS: The changes in glucose metabolism and incretin responses were different between PD and DP. The increased level of GLP-1 after DP might reflect the relatively insufficient BCF; and thus, perioperative administration of GLP-1 might improve the diabetic condition after DP.

元の言語英語
ページ(範囲)455-460
ページ数6
ジャーナルPancreas
41
発行部数3
DOI
出版物ステータス出版済み - 4 1 2012

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Incretins
Pancreatectomy
Pancreaticoduodenectomy
Glucagon-Like Peptide 1
Glucose
Peptides
Insulin Resistance
Homeostasis
Insulin
Glucose Tolerance Test

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

これを引用

Different incretin responses after pancreatoduodenectomy and distal pancreatectomy. / Mori, Yasuhisa; Takao, Ohtsuka; Tsutsumi, Kosuke; Yasui, Takaharu; Ueda, Junji; Takahata, Shunichi; Nakamura, Masafumi; Tanaka, Masao.

:: Pancreas, 巻 41, 番号 3, 01.04.2012, p. 455-460.

研究成果: ジャーナルへの寄稿記事

Mori, Yasuhisa ; Takao, Ohtsuka ; Tsutsumi, Kosuke ; Yasui, Takaharu ; Ueda, Junji ; Takahata, Shunichi ; Nakamura, Masafumi ; Tanaka, Masao. / Different incretin responses after pancreatoduodenectomy and distal pancreatectomy. :: Pancreas. 2012 ; 巻 41, 番号 3. pp. 455-460.
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AU - Ueda, Junji

AU - Takahata, Shunichi

AU - Nakamura, Masafumi

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