Different roles played by periostin splice variants in retinal neovascularization

Takahito Nakama, Shigeo Yoshida, Keijiro Ishikawa, Yoshiyuki Kobayashi, Takaya Abe, Hiroshi Kiyonari, Go Shioi, Naruto Katsuragi, Tatsuro Ishibashi, Ryuichi Morishita, Yoshiaki Taniyama

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Retinal neovascularization (NV) due to retinal ischemia is one of the major causes of vision reduction in patients with different types of retinal diseases although anti-vascular endothelial growth factor (anti-VEGF) therapy can partially reduce the size of the retinal NV. We recently reported that periostin plays an important role in the development of NV and the formation of preretinal fibrovascular membranes, but the role of the splice variants of periostin on retinal NV has not been determined. We examined the expressions of periostin splice variants in the ischemic retinas of a mouse model of oxygen-induced retinal NV. We also studied the function of periostin splice variants on retinal NV using periostin knock out mice, and the effects of anti-periostin antibodies on retinal NV. Our results showed that the expressions of the periostin splice variants were increased in ischemic retinas. The degree of increase of periostin lacking exon 17 was the highest among the periostin splice variants examined. Both genetic ablation of periostin exons 17 and 21 and antibodies for periostin exons 17 and 21 affected preretinal pathological NV. Inhibition of exon 17 of periostin had the greatest effect in reducing preretinal pathological NV. These findings suggest a causal link between periostin splice variants and retinal NV, and an intravitreal injection of antibody for exon 17 and exon 21 of periostin should be considered to inhibit preretinal pathological NV.

元の言語英語
ページ(範囲)133-140
ページ数8
ジャーナルExperimental Eye Research
153
DOI
出版物ステータス出版済み - 12 1 2016

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Retinal Neovascularization
Exons
Pathologic Neovascularization
Retina
Retinal Diseases
Intravitreal Injections
Antibodies
Knockout Mice
Vascular Endothelial Growth Factor A
Anti-Idiotypic Antibodies
Ischemia
Oxygen
Membranes

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

これを引用

Different roles played by periostin splice variants in retinal neovascularization. / Nakama, Takahito; Yoshida, Shigeo; Ishikawa, Keijiro; Kobayashi, Yoshiyuki; Abe, Takaya; Kiyonari, Hiroshi; Shioi, Go; Katsuragi, Naruto; Ishibashi, Tatsuro; Morishita, Ryuichi; Taniyama, Yoshiaki.

:: Experimental Eye Research, 巻 153, 01.12.2016, p. 133-140.

研究成果: ジャーナルへの寄稿記事

Nakama, T, Yoshida, S, Ishikawa, K, Kobayashi, Y, Abe, T, Kiyonari, H, Shioi, G, Katsuragi, N, Ishibashi, T, Morishita, R & Taniyama, Y 2016, 'Different roles played by periostin splice variants in retinal neovascularization', Experimental Eye Research, 巻. 153, pp. 133-140. https://doi.org/10.1016/j.exer.2016.10.012
Nakama, Takahito ; Yoshida, Shigeo ; Ishikawa, Keijiro ; Kobayashi, Yoshiyuki ; Abe, Takaya ; Kiyonari, Hiroshi ; Shioi, Go ; Katsuragi, Naruto ; Ishibashi, Tatsuro ; Morishita, Ryuichi ; Taniyama, Yoshiaki. / Different roles played by periostin splice variants in retinal neovascularization. :: Experimental Eye Research. 2016 ; 巻 153. pp. 133-140.
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