Differential diagnosis of suspected multiple sclerosis

A consensus approach

D. H. Miller, B. G. Weinshenker, M. Filippi, B. L. Banwell, J. A. Cohen, M. S. Freedman, S. L. Galetta, M. Hutchinson, R. T. Johnson, L. Kappos, Jun-Ichi Kira, F. D. Lublin, H. F. McFarland, X. Montalban, H. Panitch, J. R. Richert, S. C. Reingold, Chris H. Polman

研究成果: ジャーナルへの寄稿評論記事

425 引用 (Scopus)

抄録

Background and objectives: Diagnosis of multiple sclerosis (MS) requires exclusion of diseases that could better explain the clinical and paraclinical findings. A systematic process for exclusion of alternative diagnoses has not been defined. An International Panel of MS experts developed consensus perspectives on MS differential diagnosis. Methods:Using available literature and consensus, we developed guidelines for MS differential diagnosis, focusing on exclusion of potential MS mimics, diagnosis of common initial isolated clinical syndromes, and differentiating between MS and non-MS idiopathic inflammatory demyelinating diseases. Results: We present recommendations for 1) clinical and paraclinical red flags suggesting alternative diagnoses to MS; 2) more precise definition of "clinically isolated syndromes" (CIS), often the first presentations of MS or its alternatives; 3) algorithms for diagnosis of three common CISs related to MS in the optic nerves, brainstem, and spinal cord; and 4) a classification scheme and diagnosis criteria for idiopathic inflammatory demyelinating disorders of the central nervous system. Conclusions: Differential diagnosis leading to MS or alternatives is complex and a strong evidence base is lacking. Consensus-determined guidelines provide a practical path for diagnosis and will be useful for the non-MS specialist neurologist. Recommendations are made for future research to validate and support these guidelines. Guidance on the differential diagnosis process when MS is under consideration will enhance diagnostic accuracy and precision.

元の言語英語
ページ(範囲)1157-1174
ページ数18
ジャーナルMultiple Sclerosis
14
発行部数9
DOI
出版物ステータス出版済み - 1 1 2008

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Multiple Sclerosis
Differential Diagnosis
Demyelinating Diseases
Sclerosis
Guidelines
Optic Nerve
Brain Stem
Spinal Cord
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Miller, D. H., Weinshenker, B. G., Filippi, M., Banwell, B. L., Cohen, J. A., Freedman, M. S., ... Polman, C. H. (2008). Differential diagnosis of suspected multiple sclerosis: A consensus approach. Multiple Sclerosis, 14(9), 1157-1174. https://doi.org/10.1177/1352458508096878

Differential diagnosis of suspected multiple sclerosis : A consensus approach. / Miller, D. H.; Weinshenker, B. G.; Filippi, M.; Banwell, B. L.; Cohen, J. A.; Freedman, M. S.; Galetta, S. L.; Hutchinson, M.; Johnson, R. T.; Kappos, L.; Kira, Jun-Ichi; Lublin, F. D.; McFarland, H. F.; Montalban, X.; Panitch, H.; Richert, J. R.; Reingold, S. C.; Polman, Chris H.

:: Multiple Sclerosis, 巻 14, 番号 9, 01.01.2008, p. 1157-1174.

研究成果: ジャーナルへの寄稿評論記事

Miller, DH, Weinshenker, BG, Filippi, M, Banwell, BL, Cohen, JA, Freedman, MS, Galetta, SL, Hutchinson, M, Johnson, RT, Kappos, L, Kira, J-I, Lublin, FD, McFarland, HF, Montalban, X, Panitch, H, Richert, JR, Reingold, SC & Polman, CH 2008, 'Differential diagnosis of suspected multiple sclerosis: A consensus approach', Multiple Sclerosis, 巻. 14, 番号 9, pp. 1157-1174. https://doi.org/10.1177/1352458508096878
Miller DH, Weinshenker BG, Filippi M, Banwell BL, Cohen JA, Freedman MS その他. Differential diagnosis of suspected multiple sclerosis: A consensus approach. Multiple Sclerosis. 2008 1 1;14(9):1157-1174. https://doi.org/10.1177/1352458508096878
Miller, D. H. ; Weinshenker, B. G. ; Filippi, M. ; Banwell, B. L. ; Cohen, J. A. ; Freedman, M. S. ; Galetta, S. L. ; Hutchinson, M. ; Johnson, R. T. ; Kappos, L. ; Kira, Jun-Ichi ; Lublin, F. D. ; McFarland, H. F. ; Montalban, X. ; Panitch, H. ; Richert, J. R. ; Reingold, S. C. ; Polman, Chris H. / Differential diagnosis of suspected multiple sclerosis : A consensus approach. :: Multiple Sclerosis. 2008 ; 巻 14, 番号 9. pp. 1157-1174.
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title = "Differential diagnosis of suspected multiple sclerosis: A consensus approach",
abstract = "Background and objectives: Diagnosis of multiple sclerosis (MS) requires exclusion of diseases that could better explain the clinical and paraclinical findings. A systematic process for exclusion of alternative diagnoses has not been defined. An International Panel of MS experts developed consensus perspectives on MS differential diagnosis. Methods:Using available literature and consensus, we developed guidelines for MS differential diagnosis, focusing on exclusion of potential MS mimics, diagnosis of common initial isolated clinical syndromes, and differentiating between MS and non-MS idiopathic inflammatory demyelinating diseases. Results: We present recommendations for 1) clinical and paraclinical red flags suggesting alternative diagnoses to MS; 2) more precise definition of {"}clinically isolated syndromes{"} (CIS), often the first presentations of MS or its alternatives; 3) algorithms for diagnosis of three common CISs related to MS in the optic nerves, brainstem, and spinal cord; and 4) a classification scheme and diagnosis criteria for idiopathic inflammatory demyelinating disorders of the central nervous system. Conclusions: Differential diagnosis leading to MS or alternatives is complex and a strong evidence base is lacking. Consensus-determined guidelines provide a practical path for diagnosis and will be useful for the non-MS specialist neurologist. Recommendations are made for future research to validate and support these guidelines. Guidance on the differential diagnosis process when MS is under consideration will enhance diagnostic accuracy and precision.",
author = "Miller, {D. H.} and Weinshenker, {B. G.} and M. Filippi and Banwell, {B. L.} and Cohen, {J. A.} and Freedman, {M. S.} and Galetta, {S. L.} and M. Hutchinson and Johnson, {R. T.} and L. Kappos and Jun-Ichi Kira and Lublin, {F. D.} and McFarland, {H. F.} and X. Montalban and H. Panitch and Richert, {J. R.} and Reingold, {S. C.} and Polman, {Chris H.}",
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T1 - Differential diagnosis of suspected multiple sclerosis

T2 - A consensus approach

AU - Miller, D. H.

AU - Weinshenker, B. G.

AU - Filippi, M.

AU - Banwell, B. L.

AU - Cohen, J. A.

AU - Freedman, M. S.

AU - Galetta, S. L.

AU - Hutchinson, M.

AU - Johnson, R. T.

AU - Kappos, L.

AU - Kira, Jun-Ichi

AU - Lublin, F. D.

AU - McFarland, H. F.

AU - Montalban, X.

AU - Panitch, H.

AU - Richert, J. R.

AU - Reingold, S. C.

AU - Polman, Chris H.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Background and objectives: Diagnosis of multiple sclerosis (MS) requires exclusion of diseases that could better explain the clinical and paraclinical findings. A systematic process for exclusion of alternative diagnoses has not been defined. An International Panel of MS experts developed consensus perspectives on MS differential diagnosis. Methods:Using available literature and consensus, we developed guidelines for MS differential diagnosis, focusing on exclusion of potential MS mimics, diagnosis of common initial isolated clinical syndromes, and differentiating between MS and non-MS idiopathic inflammatory demyelinating diseases. Results: We present recommendations for 1) clinical and paraclinical red flags suggesting alternative diagnoses to MS; 2) more precise definition of "clinically isolated syndromes" (CIS), often the first presentations of MS or its alternatives; 3) algorithms for diagnosis of three common CISs related to MS in the optic nerves, brainstem, and spinal cord; and 4) a classification scheme and diagnosis criteria for idiopathic inflammatory demyelinating disorders of the central nervous system. Conclusions: Differential diagnosis leading to MS or alternatives is complex and a strong evidence base is lacking. Consensus-determined guidelines provide a practical path for diagnosis and will be useful for the non-MS specialist neurologist. Recommendations are made for future research to validate and support these guidelines. Guidance on the differential diagnosis process when MS is under consideration will enhance diagnostic accuracy and precision.

AB - Background and objectives: Diagnosis of multiple sclerosis (MS) requires exclusion of diseases that could better explain the clinical and paraclinical findings. A systematic process for exclusion of alternative diagnoses has not been defined. An International Panel of MS experts developed consensus perspectives on MS differential diagnosis. Methods:Using available literature and consensus, we developed guidelines for MS differential diagnosis, focusing on exclusion of potential MS mimics, diagnosis of common initial isolated clinical syndromes, and differentiating between MS and non-MS idiopathic inflammatory demyelinating diseases. Results: We present recommendations for 1) clinical and paraclinical red flags suggesting alternative diagnoses to MS; 2) more precise definition of "clinically isolated syndromes" (CIS), often the first presentations of MS or its alternatives; 3) algorithms for diagnosis of three common CISs related to MS in the optic nerves, brainstem, and spinal cord; and 4) a classification scheme and diagnosis criteria for idiopathic inflammatory demyelinating disorders of the central nervous system. Conclusions: Differential diagnosis leading to MS or alternatives is complex and a strong evidence base is lacking. Consensus-determined guidelines provide a practical path for diagnosis and will be useful for the non-MS specialist neurologist. Recommendations are made for future research to validate and support these guidelines. Guidance on the differential diagnosis process when MS is under consideration will enhance diagnostic accuracy and precision.

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JO - Multiple Sclerosis

JF - Multiple Sclerosis

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